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| Item Type: | Editorial |
|---|---|
| Title: | Do CARs need a driver's license? Adoptive cell therapy with chimeric antigen receptor-redirected T cells caused serious adverse events |
| Creators Name: | Buening, H., Uckert, W., Cichutek, K., Hawkins, R.E. and Abken, H. |
| Abstract: | Adoptive transfer of genetically retargeted T cells provides promise in the therapy of malignant diseases; two severe adverse events, however, due to "on-targeted" activation of modified T cells occurred in recent trials. We here discuss the challenge to balance targeted anti-tumor responses whilst avoiding destruction of healthy tissues and the need of continued and carefully designed pre-clinical and clinical evaluations. |
| Keywords: | Adoptive Immunotherapy, Antigen Receptors, Clinical Trials, Lymphocyte Activation, Recombinant Proteins, T-Lymphocytes, Animals, Mice |
| Source: | Human Gene Therapy |
| ISSN: | 1043-0342 |
| Publisher: | Mary Ann Liebert |
| Volume: | 21 |
| Number: | 9 |
| Page Range: | 1039-1042 |
| Date: | September 2010 |
| Official Publication: | https://doi.org/10.1089/hum.2010.131 |
| PubMed: | View item in PubMed |
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