Specific removal of C-reactive protein by apheresis in a porcine cardiac infarction model

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Item Type:	Article
Title:	Specific removal of C-reactive protein by apheresis in a porcine cardiac infarction model
Creators Name:	Slagman, A.C., Bock, C., Abdel-Aty, H., Vogt, B., Gebauer, F., Janelt, G., Wohlgemuth, F., Morgenstern, R., Yapici, G., Puppe, A., Modersohn, D., Mans, D., Jerichow, T., Ott, S., Kunze, R., Schroedl, W., Janko, C., Hermann, M., Kalden, J.R., Kern, P., Parsch, H., Kirschfink, M., Schulz-Menger, J., Roettgen, R., Unger, J.K., Frei, U., Schindler, R., Moeckel, M. and Sheriff, A.
Abstract:	Background: C-reactive protein (CRP) is a possible causative factor of the destructive processes observed during the weeks after myocardial infarction. Methods: We developed a clinically relevant animal model including the removal of CRP from blood plasma utilizing a specific CRP adsorber and the visualization of the infarct scar in the living animal by cardiovascular magnetic resonance imaging as a tool to investigate the impact of CRP after acute myocardial infarction. Results: We describe the facets of this model system and kinetics of clinical blood parameters like CRP and troponin. In addition, we demonstrate the potency of CRP apheresis reducing CRP levels by ∼70% in the established treatment system. Conclusion: We showed for the first time that it is possible to conduct apheresis at the following 2 days after acute myocardial infarction in a porcine infarction model and to analyze the infarct by cardiovascular magnetic resonance imaging at day 1 and 14.
Keywords:	Acute Myocardial Infarction, Acute Phase Protein, Adsorber, Apheresis, C-Reactive Protein
Source:	Blood Purification
ISSN:	0253-5068
Publisher:	Karger
Volume:	31
Number:	1-3
Page Range:	9-17
Date:	2011
Official Publication:	https://doi.org/10.1159/000320763
PubMed:	View item in PubMed

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