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| Item Type: | Article |
|---|---|
| Title: | Angiotensin-(1-7)/Mas axis integrity is required for the expression of object recognition memory |
| Creators Name: | Lazaroni, T.L.N., Raslan, A.C.S., Fontes, W.R.P., de Oliveira, M.L., Bader, M., Alenina, N., Moraes, M.F.D., Dos Santos, R.A. and Pereira, G.S. |
| Abstract: | It has been shown that the brain has its own intrinsic renin-angiotensin system (RAS) and angiotensin-(1-7) (Ang-(1-7)) is particularly interesting, because it appears to counterbalance most of the Ang II effects. Ang-(1-7) exerts its biological function through activation of the G-protein-coupled receptor Mas. Interestingly, hippocampus is one of the regions with higher expression of Mas. However, the role of Ang-(1-7)/Mas axis in hippocampus-dependent memories is still poorly understood. Here we demonstrated that Mas ablation, as well as the blockade of Mas in the CA1-hippocampus, impaired object recognition memory (ORM). We also demonstrated that the blockade of Ang II receptors AT1, but not AT2, recovers ORM impairment of Mas-deficient mice. Considering that high concentrations of Ang-(1-7) may activate AT1 receptors, nonspecifically, we evaluate the levels of Ang-(1-7) and its main precursors Ang I and Ang II in the hippocampus of Mas-deficient mice. The Ang I and Ang II levels are unaltered in the whole hipocampus of MasKo. However, Ang-(1-7) concentration is increased in the whole hippocampus of MasKo mice, as well as in the CA1 area. Taken together, our findings suggest that the functionality of the Ang-(1-7)/Mas axis is essential for normal ORM processing. |
| Keywords: | Angiotensin-(1-7), Receptor Mas, Object Recognition Memory, AT1 Receptor, Animals, Mice |
| Source: | Neurobiology of Learning and Memory |
| ISSN: | 1074-7427 |
| Publisher: | Elsevier / Academic Press |
| Volume: | 97 |
| Number: | 1 |
| Page Range: | 113-123 |
| Date: | January 2012 |
| Official Publication: | https://doi.org/10.1016/j.nlm.2011.10.003 |
| PubMed: | View item in PubMed |
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