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| Item Type: | Article |
|---|---|
| Title: | Differential cAMP signaling at hippocampal output synapses |
| Creators Name: | Wozny, C., Maier, N., Fidzinski, P., Breustedt, J., Behr, J. and Schmitz, D. |
| Abstract: | cAMP is a critical second messenger involved in synaptic transmission and synaptic plasticity. Here, we show that activation of the adenylyl cyclase by forskolin and application of the cAMP-analog Sp-5,6-DCl-cBIMPS both mimicked and occluded tetanus-induced long-term potentiation (LTP) in subicular bursting neurons, but not in subicular regular firing cells. Furthermore, LTP in bursting cells was inhibited by protein kinase A (PKA) inhibitors Rp-8-CPT-cAMP and H-89. Variations in the degree of EPSC blockade by the low-affinity competitive AMPA receptor-antagonist {gamma}-d-glutamyl-glycine ({gamma}-DGG), analysis of the coefficient of variance as well as changes in short-term potentiation suggest an increase of glutamate concentration in the synaptic cleft after expression of LTP. We conclude that presynaptic LTP in bursting cells requires activation of PKA by a calcium-dependent adenylyl cyclase while LTP in regular firing cells is independent of elevated cAMP levels. Our results provide evidence for a differential role of cAMP in LTP at hippocampal output synapses. |
| Keywords: | Bursting, cAMP, Forskolin, LTP, Subiculum, Hippocampus, Animals, Rats |
| Source: | Journal of Neuroscience |
| ISSN: | 0270-6474 |
| Publisher: | Society for Neuroscience |
| Volume: | 28 |
| Number: | 53 |
| Page Range: | 14358-14362 |
| Date: | 31 December 2008 |
| Additional Information: | Copyright © 2008 Society for Neuroscience |
| Official Publication: | https://doi.org/10.1523/JNEUROSCI.4973-08.2008 |
| PubMed: | View item in PubMed |
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