Identical lesion morphology in primary progressive and relapsing-remitting MS -an ultrahigh field MRI study

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Item Type:	Article
Title:	Identical lesion morphology in primary progressive and relapsing-remitting MS -an ultrahigh field MRI study
Creators Name:	Kuchling, J., Ramien, C., Bozin, I., Dörr, J., Harms, L., Rosche, B., Niendorf, T., Paul, F., Sinnecker, T. and Wuerfel, J.
Abstract:	Potential differences between primary progressive (PP) and relapsing-remitting (RR) multiple sclerosis (MS) have been controversially discussed. In this study, we compared lesion morphology and distribution in patients with PPMS and RRMS (nine in each group) using 7 T MRI. We found that gray and white matter lesions in PPMS and RRMS patients did not differ in their respective morphological characteristics (e.g. perivascular p = 0.863, hypointense rim p = 0.796, cortical lesion count p = 0.436). Although limited by a small sample size, our study results suggest that PPMS and RRMS, despite differences in disease course and clinical characteristics, exhibit identical lesion morphology under ultrahigh field MRI.
Keywords:	MRI, Primary Progressive Multiple Sclerosis, PPMS, Relapsing-Remitting Multiple Sclerosis, RRMS, Ultrahigh Field MRI, 7 T MRI
Source:	Multiple Sclerosis Journal
ISSN:	1352-4585
Publisher:	Sage Publications
Volume:	20
Number:	14
Page Range:	1866-1871
Date:	December 2014
Official Publication:	https://doi.org/10.1177/1352458514531084
PubMed:	View item in PubMed

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