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| Item Type: | Article |
|---|---|
| Title: | Designer T cells - New possibilities for immunotherapy of cancer [Designer-T-Zellen - neue Möglichkeiten für die Immuntherapie von Krebs] |
| Creators Name: | Leisegang, M. and Uckert, W. |
| Abstract: | The genetic engineering of T cells with T cell or chimeric antigen receptors generates tumor-specific designer T cells for immunotherapy of cancer. The clinical use of these cells requires (1) careful selection of the target antigen that should be tumor-specific, (2) an optimized configuration of therapeutic genes, to generate T cells of high functional activity and (3) efficient vector systems that allow the generation of sufficient numbers of engineered T cells within a short period of time. |
| Source: | BIOspektrum |
| ISSN: | 0947-0867 |
| Publisher: | Springer / Spektrum Akademischer Verlag |
| Volume: | 21 |
| Number: | 4 |
| Page Range: | 402-405 |
| Date: | June 2015 |
| Official Publication: | https://doi.org/10.1007/s12268-015-0594-7 |
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