![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
![[thumbnail of 15606oa.pdf]](https://mdc-test.eprints-hosting.org/style/images/fileicons/application_pdf.png) |
PDF
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
326kB |
| Item Type: | Article |
|---|---|
| Title: | Environmental factors in early childhood are associated with multiple sclerosis: a case-control study |
| Creators Name: | Conradi, S., Malzahn, U., Schroeter, F., Paul, F., Quill, S., Spruth, E., Harms, L., Then Bergh, F., Ditzenbach, A., Georgi, T., Heuschmann, P. and Rosche, B. |
| Abstract: | Background: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) with increasing incidence mainly in high-income countries. One explanation of this phenomenon may be a higher prevalence of allergic and autoimmune diseases in industrialized countries as a consequence of otherwise beneficial advances in sanitation (hygiene hypothesis). We investigated environmental factors in early childhood associated with MS. Methods: A case-control study was performed of 245 MS patients and 296 population-based controls in Berlin. The study participants completed a standardized questionnaire on environmental factors in childhood and youth, including aspects of personal and community hygiene. Multivariable logistic regression analysis was performed to investigate factors in childhood and youth associated with the occurrence of MS. Results: Mean age was 46 years (range, 20-80) in the MS group and 42 years (range 18-80) in the control group, of which 73.9% in the MS and 61.5% in the control group were female. The multivariable analysis showed that having at least two older siblings (OR 0.54; p = 0.05, for individuals with two older siblings compared to individuals without older siblings), attending a day-care center (OR 0.5; p = 0.004) and growing up in an urban center with more than 100, 000 inhabitants (OR 0.43; p = 0.009) were factors independently associated with a lower chance for MS. Conclusions: The hygiene hypothesis may play a role in the occurrence of MS and could explain disease distribution and increasing incidence. |
| Keywords: | Berlin, Case-Control Studies, Developed Countries, Environment, Environmental Exposure, Hygiene Hypothesis, Incidence, Multiple Sclerosis, Risk Factors |
| Source: | BMC Neurology |
| ISSN: | 1471-2377 |
| Publisher: | BioMed Central |
| Volume: | 11 |
| Page Range: | 123 |
| Date: | 6 October 2011 |
| Official Publication: | https://doi.org/10.1186/1471-2377-11-123 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
