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| Item Type: | Article |
|---|---|
| Title: | Omentin-1 and risk of myocardial infarction and stroke: results from the EPIC-Potsdam cohort study |
| Creators Name: | Menzel, J., di Giuseppe, R., Biemann, R., Wittenbecher, C., Aleksandrova, K., Pischon, T., Fritsche, A., Schulze, M.B., Boeing, H., Isermann, B. and Weikert, C. |
| Abstract: | BACKGROUND AND AIMS: The recently identified adipokine omentin-1 is inversely associated with body fatness, metabolic syndrome and cardiovascular disease (CVD) in cross-sectional analyses. However, prospective data on the association between plasma omentin-1 levels and future risk of CVD are lacking. The aim of the study was to investigate the relationship between omentin-1 and incident myocardial infarction (MI) and stroke. METHODS: We conducted a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort comprising a subsample of 2084 participants, including 50 CVD cases and 350 external incident CVD cases (mean follow-up of 8.2 +/- 1.6 years). Prentice modified Cox regression adjusted for established CVD risk factors was used to estimate associations between omentin-1 and risk of MI and stroke, interactions were tested with cross-product terms. RESULTS: After multivariable adjustment, omentin-1 was not significantly associated with risk of MI (HR per doubling omentin-1:1.17; 95%-CI:0.79-1.72; p = 0.43), but with higher risk of stroke (HR per doubling omentin-1:2.22; 95%-CI:1.52-3.22; p < 0.0001). In subgroup analyses, associations between omentin-1 and stroke risk were generally stronger in lower versus higher CVD risk groups. For example, risk of stroke was stronger in participants without metabolic syndrome (HR per doubling omentin-1:2.58; 95%-CI:1.64-4.07; p < 0.0001) compared to those with metabolic syndrome (HR per doubling omentin-1:1.21; 95%-CI:0.59-2.50; p = 0.60) (p for interaction = 0.05). Similar interactions were observed when participants were classified in low or high risk groups according to waist circumference, triglyceride, hsCRP or adiponectin levels. CONCLUSIONS: Omentin-1 concentrations may be related to increased stroke risk. This association is stronger in metabolically healthy individuals. |
| Keywords: | Adipokines, Intelectin-1, Risk Factor, Adiponectin |
| Source: | Atherosclerosis |
| ISSN: | 0021-9150 |
| Publisher: | Elsevier |
| Volume: | 251 |
| Page Range: | 415-421 |
| Date: | August 2016 |
| Additional Information: | Copyright © 2016 The Author(s). Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Official Publication: | https://doi.org/10.1016/j.atherosclerosis.2016.06.003 |
| PubMed: | View item in PubMed |
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