Cardiac morphofunctional characteristics of transgenic rats with overexpression of the bradykinin B1 receptor in the endothelium

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Item Type:	Article
Title:	Cardiac morphofunctional characteristics of transgenic rats with overexpression of the bradykinin B1 receptor in the endothelium
Creators Name:	Levy, R.F., Serra, A.J., Antonio, E.L., dos Santos, L., Bocalini, D.S., Pesquero, J.B., Bader, M., Merino, V.F., de Oliveira, H.A., de Arruda Veiga, E.C., Silva, J.A. and Tucci, P.J.F.
Abstract:	OBJECTIVE: Evaluate whether endothelial overexpressing of the bradykinin B1 receptor could be associated with altered left ventricular and myocardial performance. METHODS: Echocardiography and hemodynamic were employed to assess left ventricular morphology and function in Sprague-Dawley transgenic rats overexpressing the endothelial bradykinin B1 receptor (Tie2B1 rats). The myocardial inotropism was evaluated on papillary muscles contradicting in vitro. RESULTS: In Tie2B1 animals, an enlarged left ventricular cavity and lower fractional shortening coupled with a lower rate of pressure change values indicated depressed left ventricular performance. Papillary muscle mechanics revealed that both Tie2B1 and wild-type rat groups had the same contractile capacities under basal conditions; however, in transgenic animals, there was accentuated inotropism due to post-pause potentiation. Following treatment with the Arg(9)-BK agonist, Tie2B1 papillary muscles displayed a reduction in myocardial inotropism. CONCLUSIONS: Endothelial B1 receptor overexpression has expanded the LV cavity and worsened its function. There was an exacerbated response of papillary muscle in vitro to a prolonged resting pause, and the use of a B1 receptor agonist impairs myocardial inotropism.
Keywords:	Bradykinin Receptor, Cardiac Structure, Cardiac Function, Myocardial Function, Transgenic Rat, Animals, Rats
Source:	Physiological Research
ISSN:	0862-8408
Publisher:	Institute of Physiology, Czech Academy of Sciences
Volume:	66
Number:	6
Page Range:	925-932
Date:	22 September 2017
Official Publication:	http://www.biomed.cas.cz/physiolres/pdf/66/66_925.pdf
PubMed:	View item in PubMed

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