Optische Kohaerenztomografie in der Neurologie: Methodik und Anwendung in Forschung und Klinik [Optical coherence tomography in neurology: method and application in research and clinical routine]

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Item Type:	Review
Title:	Optische Kohaerenztomografie in der Neurologie: Methodik und Anwendung in Forschung und Klinik [Optical coherence tomography in neurology: method and application in research and clinical routine]
Creators Name:	Zimmermann, H.G., Brandt, A.U. and Paul, F.
Abstract:	High-resolution optical coherence tomography (OCT) as a non-invasive and rapidly applicable imaging technique is being increasingly used in clinical research and interventional trials in neurology in recent years, in particular in inflammatory diseases of the CNS. OCT is capable of detecting and quantifying damage or alterations in various retinal layers (such as the retinal nerve fiber layer, the ganglion cell layer and the inner nuclear layer) in multiple neurological conditions such as optic neuritis, multiple sclerosis, neuromyelitis optica spectrum disorders, Susac syndrome and neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease or spinocerebellar ataxias. In many studies, a good correlation between structural retinal damage measurable with OCT and functional visual impairment including visual quality of life could be demonstrated, underscoring the clinical relevance of OCT findings. Whether this technology will enter clinical routine and be found suitable for diagnosis and monitoring of individual patients with neurological conditions is a question that is currently under intensive research. This article describes the basic underpinnings of the technology, as well as the most relevant findings in various neurological disorders in relation to functional visual assessments and with an emphasis on inflammatory conditions, where most data have been gathered to date. The potential future application of OCT in clinical studies and clinical management of neurological patients is also discussed.
Keywords:	Optical Coherence Tomography, Retina, Optic Neuritis, Retinal Nerve Fiber Layer, Multiple Sclerosis
Source:	Klinische Neurophysiologie
ISSN:	1434-0275
Publisher:	Thieme
Volume:	48
Number:	4
Page Range:	211-225
Date:	December 2017
Official Publication:	https://doi.org/10.1055/s-0043-118781

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