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| Item Type: | Review |
|---|---|
| Title: | A (3D-nuclear) space odyssey: making sense of Hi-C maps |
| Creators Name: | Mota-Gómez, I. and Lupiáñez, D.G. |
| Abstract: | Three-dimensional 3D)-chromatin organization is critical for proper enhancer-promoter communication and, therefore, for a precise execution of the transcriptional programs governing cellular processes. The emergence of Chromosome Conformation Capture (3C) methods, in particular Hi-C, has allowed the investigation of chromatin interactions on a genome-wide scale, revealing the existence of overlapping molecular mechanisms that we are just starting to decipher. Therefore, disentangling Hi-C signal into these individual components is essential to provide meaningful biological data interpretation. Here, we discuss emerging views on the molecular forces shaping the genome in 3D, with a focus on their respective contributions and interdependence. We discuss Hi-C data at both population and single-cell levels, thus providing criteria to interpret genomic function in the 3D-nuclear space. |
| Keywords: | 3D-Chromatin Organization, Long-Range Gene Regulation, Chromosome Conformation Capture, Animals |
| Source: | Genes |
| ISSN: | 2073-4425 |
| Publisher: | MDPI |
| Volume: | 10 |
| Number: | 6 |
| Page Range: | 415 |
| Date: | 29 May 2019 |
| Official Publication: | https://doi.org/10.3390/genes10060415 |
| PubMed: | View item in PubMed |
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