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Item Type: | Review |
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Title: | Wie Kochsalz Mitochondrien beeinflusst |
Creators Name: | Geisberger, S. |
Abstract: | Dietary high salt (HS) is a major risk factor for cardio-vascular and chronic inflammatory diseases. Sodium can increase postprandially but can also accumulate in diverse tissues. Immune cells, such as macrophages, sense this salty environment and adapt accordingly, shifting towards a more pro-inflammatory state. Mechanistically, HS inhibits complex II of the electron transport chain and thereby reduces mitochondrial function. In two independent clinical studies, an HS-diet transiently impaired human monocytic mitochondrial function. |
Source: | BIOspektrum |
ISSN: | 0947-0867 |
Publisher: | Springer / Spektrum Akademischer Verlag |
Volume: | 28 |
Number: | 4 |
Page Range: | 387-389 |
Date: | June 2022 |
Official Publication: | https://doi.org/10.1007/s12268-022-1781-y |
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