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| Item Type: | Article |
|---|---|
| Title: | Pre-diagnostic circulating resistin concentrations are not associated with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study |
| Creators Name: | Pham, T.T., Nimptsch, K., Aleksandrova, K., Jenab, M., Reichmann, R., Wu, K., Tjønneland, A., Kyrø, C., Schulze, M.B., Kaaks, R., Katzke, V., Palli, D., Pasanisi, F., Ricceri, F., Tumino, R., Krogh, V., Roodhart, J., Castilla, J., Sánchez, M.J., Colorado-Yohar, S.M., Harbs, J., Rutegård, M., Papier, K., Aglago, E.K., Dimou, N., Mayen-Chacon, A.L., Weiderpass, E. and Pischon, T. |
| Abstract: | Resistin is a polypeptide implicated in inflammatory processes, and as such could be linked to colorectal carcinogenesis. In case-control studies, higher resistin levels have been found in colorectal cancer (CRC) patients compared to healthy individuals. However, evidence for the association between pre-diagnostic resistin and CRC risk is scarce. We investigated pre-diagnostic resistin concentrations and CRC risk within the European Prospective Investigation into Cancer and Nutrition using a nested case-control study among 1293 incident CRC-diagnosed cases and 1293 incidence density-matched controls. Conditional logistic regression models controlled for matching factors (age, sex, study center, fasting status, and women-related factors in women) and potential confounders (education, dietary and lifestyle factors, body mass index (BMI), BMI-adjusted waist circumference residuals) were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for CRC. Higher circulating resistin concentrations were not associated with CRC (RR per doubling resistin, 1.11; 95% CI 0.94-1.30; p= 0.22). There were also no associations with CRC subgroups defined by tumor subsite or sex. However, resistin was marginally associated with a higher CRC risk among participants followed-up maximally two years, but not among those followed-up after more than two years. We observed no substantial correlation between baseline circulating resistin concentrations and adiposity measures (BMI, waist circumference), adipokines (adiponectin, leptin), or metabolic and inflammatory biomarkers (C-reactive protein, C-peptide, high-density lipoprotein cholesterol, reactive oxygen metabolites) among controls. In this large-scale prospective cohort, there was little evidence of an association between baseline circulating resistin concentrations and CRC risk in European men and women. |
| Keywords: | Pre-Diagnostic Resistin, Colorectal Cancer, Risk, Prospective, Inflammation |
| Source: | Cancers |
| ISSN: | 2072-6694 |
| Publisher: | MDPI |
| Volume: | 14 |
| Number: | 22 |
| Page Range: | 5499 |
| Date: | 9 November 2022 |
| Official Publication: | https://doi.org/10.3390/cancers14225499 |
| PubMed: | View item in PubMed |
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