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| Item Type: | Article |
|---|---|
| Title: | Social play behavior is driven by glycine-dependent mechanisms |
| Creators Name: | Dvorzhak, A., Brecht, M. and Schmitz, D. |
| Abstract: | Social play is pervasive in juvenile mammals, yet it is poorly understood in terms of its underlying brain mechanisms. Specifically, we do not know why young animals are most playful and why most adults cease to social play. Here, we analyze the synaptic mechanisms underlying social play. We found that blocking the rat periaqueductal gray (PAG) interfered with social play. Furthermore, an age-related decrease of neural firing in the PAG is associated with a decrease in synaptic release of glycine. Most importantly, modulation of glycine concentration—apparently acting on the glycinergic binding site of the N-methyl-D-aspartate (NMDA) receptor—not only strongly modulates social play but can also reverse the age-related decline in social play. In conclusion, we demonstrate that social play critically depends on the neurotransmitter glycine within the PAG. |
| Keywords: | Social Play, Glycine, Midbrain, Periaqueductal Gray, Synaptic Plasticity, NMDA Receptors, Aging, Optogenetics, Instinctive Behaviors, Rough and Tumble Play, Animals, Rats |
| Source: | Current Biology |
| ISSN: | 0960-9822 |
| Publisher: | Cell Press |
| Volume: | 34 |
| Number: | 16 |
| Page Range: | 3654-3664.e6 |
| Date: | 19 August 2024 |
| Official Publication: | https://doi.org/10.1016/j.cub.2024.06.073 |
| PubMed: | View item in PubMed |
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