Item Type: | Review |
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Title: | Biochemical interactions in the wnt pathway |
Creators Name: | Seidensticker, M.J. and Behrens, J. |
Abstract: | The wnt signal transduction pathway is involved in many differentiation events during embryonic development and can lead to tumor formation after aberrant activation of its components. The cytoplasmic component {beta}-catenin is central to the transmission of wnt signals to the nucleus: in the absence of wnts {beta} catenin is constitutively degraded in proteasomes, whereas in the presence of wnts β-catenin is stabilized and associates with HMG box transcription factors of the LEF/TCF family. In tumors, {beta}-catenin degradation is blocked by mutations of the tumor suppressor gene APC (adenomatous polyposis coli), or of {beta}-catenin itself. As a consequence, constitutive TCF/{beta}-catenin complexes are formed and activate oncogenic target genes. This review discusses the mechanisms that silence the pathway in cells that do not receive a wnt signal and goes on to describe the regulatory steps involved in the activation of the pathway. |
Keywords: | {Beta}- Catenin, Adenomatous Polyposis Coli, Gene Expression, TCF Family, Tumor Development, Wnt Signal Transduction, Animals, Mice |
Source: | Biochimica et Biophysica Acta - Molecular Cell Research |
ISSN: | 0167-4889 |
Publisher: | Elsevier |
Volume: | 1495 |
Number: | 2 |
Page Range: | 168-182 |
Date: | 2 February 2000 |
Official Publication: | https://doi.org/10.1016/S0167-4889(99)00158-5 |
PubMed: | View item in PubMed |
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