Identification of a recurrent BRCA1 mutation in German breast-cancer and/or ovarian-cancer families

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Item Type:	Article
Title:	Identification of a recurrent BRCA1 mutation in German breast-cancer and/or ovarian-cancer families
Creators Name:	Hofmann, W., Jandrig, B., Classen, E., Nestle-Kraemling, C., Chang-Claude, J. and Scherneck, S.
Abstract:	Specific BRCA1 mutations have been reported to be common within particular populations. We have investigated German breast- and/or ovarian-cancer families and detected a recurrent carboxy-terminal BRCA1 mutation, 5622C > T, using PCR-based restriction assay and haplotype analysis. Unrelated families carrying this BRCA1 mutation shared two different disease-associated haplotypes, indicating two independent mutation events.
Keywords:	BRCA1, Hereditary Breast Cancer, Mutation, Ovarian Cancer
Source:	Journal of Cancer Research and Clinical Oncology
ISSN:	0171-5216
Publisher:	Springer
Volume:	127
Number:	3
Page Range:	200-202
Date:	1 January 2001
PubMed:	View item in PubMed

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