Use of beta-blockers in obesity hypertension: potential role of weight gain

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Item Type:	Article
Title:	Use of beta-blockers in obesity hypertension: potential role of weight gain
Creators Name:	Pischon, T. and Sharma, A.M.
Abstract:	Beta-blockers are the most frequently used drugs for the treatment of hypertension. Apart from concerns regarding potential adverse metabolic effects on lipids or insulin sensitivity, beta-blockers can also cause weight gain in some patients. This fact appears little known to clinical practitioners and trialists. Thus, only a minority of clinical trials with beta-blockers report weight changes during treatment. In trials that do report weight changes, beta-blockers are associated with a weight gain of 1.2 (range -0.4-3.5) kg. This may be attributable to the fact that beta blockade can decrease metabolic rate by 10%. Beta-blockers may also have other negative effects on energy metabolism. Obesity management in overweight hypertensive patients may therefore be more difficult in the presence of beta-blocker treatment. We therefore question the use of beta-blockers as first-line therapy for overweight or obese patients with uncomplicated hypertension.
Keywords:	Obesity, Beta-Blockers, Body Weight, Weight Gain, Hypertension
Source:	Obesity Reviews
ISSN:	1467-7881
Publisher:	Blackwell Publishing
Volume:	2
Number:	4
Page Range:	275-280
Date:	November 2001
Official Publication:	https://doi.org/10.1046/j.1467-789X.2001.00044.x
PubMed:	View item in PubMed

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