Genetic interaction between Wnt/β-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb

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Item Type:	Article
Title:	Genetic interaction between Wnt/β-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb
Creators Name:	Soshnikova, N., Zechner, D., Huelsken, J., Mishina, Y., Behringer, R.R., Taketo, M.M., Crenshaw, E.B. and Birchmeier, W.
Abstract:	By conditional gene ablation in mice, we found that {beta}-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator of formation of the apical ectodermal ridge (AER) and of the dorsal-ventral axis of the limbs. By generation of compound mutants, we also show that {beta}-catenin acts downstream of the BMP receptor IA in AER induction, but upstream or parallel in dorsal-ventral patterning. Thus, AER formation and dorsal-ventral patterning of limbs are tightly controlled by an intricate interplay between Wnt/{beta}-catenin and BMP receptor signaling.
Keywords:	Engrailed-1, FGF, Frizzled, Limb Ventral Ectoderm, Proximal-Distal Axis, Animals, Mice
Source:	Genes & Development
ISSN:	0890-9369
Publisher:	Cold Spring Harbor Laboratory Press
Volume:	17
Number:	16
Page Range:	1963-1968
Date:	1 January 2003
Official Publication:	https://doi.org/10.1101/gad.263003
PubMed:	View item in PubMed

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