Oncogene-induced senescence: putting the brakes on tumor development

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Item Type:	Review
Title:	Oncogene-induced senescence: putting the brakes on tumor development
Creators Name:	Braig, M. and Schmitt, C.A.
Abstract:	Cellular senescence, a permanent cell cycle arrest, is considered a safeguard mechanism that may prevent aged or abnormal cells from further expansion. Although the term ‘‘replicative senescence’’ stands for the widely accepted model of a terminal growth arrest due to telomere attrition, the significance of ‘‘oncogene-inducible senescence’’ remained an issue of debate over the years. A number of recent studies now show the effect of this acute and telomere-independent form of senescence as a tumor-protective, fail-safe mechanism in vivo that shares conceptual and possibly therapeutic similarities with the genetically encoded apoptosis machinery. (Cancer Res 2006; 66(6): 2881-4)
Keywords:	Cell Aging, Neoplastic Cell Transformation, Oncogenes, Precancerous Conditions, Animals
Source:	Cancer Research
ISSN:	0008-5472
Publisher:	American Association for Cancer Research
Volume:	66
Number:	6
Page Range:	2881-2884
Date:	15 March 2006
Official Publication:	https://doi.org/10.1158/0008-5472.CAN-05-4006
PubMed:	View item in PubMed

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