Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation

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Item Type:	Article
Title:	Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation
Creators Name:	Loeffler, J., Steffens, M., Arlt, E.M., Toliat, M.R., Mezger, M., Suk, A., Wienker, T.F., Hebart, H., Nuernberg, P., Boeckh, M., Ljungman, P., Trenschel, R. and Einsele, H.
Abstract:	We analyzed 90 polymorphisms in 17 genes related to immune function for association with human cytomegalovirus (HCMV) reactivation and disease in patients after allogeneic stem cell transplantation. We found relevant markers (i) in CCR5 and IL-10 genes conferring a higher risk for the development of HCMV disease and (ii) in the MCP1 gene associated with HCMV reactivation. Testing of high-risk patients for the presence of these single-nucleotide polymorphisms might be useful for individualizing antiviral prophylaxis.
Source:	Journal of Clinical Microbiology
ISSN:	0095-1137
Publisher:	American Society for Microbiology
Volume:	44
Page Range:	1847-1850
Date:	May 2006
Official Publication:	https://doi.org/10.1128/JCM.44.5.1847-1850.2006
PubMed:	View item in PubMed

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