Atrial natriuretic peptide induces postprandial lipid oxidation in humans

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Item Type:	Article
Title:	Atrial natriuretic peptide induces postprandial lipid oxidation in humans
Creators Name:	Birkenfeld, A.L., Budziarek, P., Boschmann, M., Moro, C., Adams, F., Franke, G., Berlan, M., Marques, M.A., Sweep, F.C., Luft, F.C., Lafontan, M. and Jordan, J.
Abstract:	OBJECTIVE-Atrial natriuretic peptide (ANP) regulates arterial blood pressure. In addition, ANP has recently been shown to promote human adipose tissue lipolysis through cGMP-mediated hormone-sensitive lipase activation. We hypothesized that ANP increases postprandial free fatty acid (FFA) availability and energy expenditure while decreasing arterial blood pressure. RESEARCH DESIGN AND METHODS-We infused human ANP (25 ng . kg(-1) . min(-1)) in 12 men (age 32 +/- 0.8 years, BMI 23.3 +/- 0.4 kg/m(2)) before, during, and 2 h after ingestion of a standardized high-fat test meal in a randomized, double-blind, cross-over fashion. Cardiovascular changes were monitored by continuous electrocardiogram and beat-by-beat blood pressure recordings. Metabolism was monitored through venous blood sampling, intramuscular and subcutaneous abdominal adipose tissue microdialysis, and indirect calorimetry. RESULTS-ANP infusion decreased mean arterial blood pressure by 4 mmHg during the postprandial phase (P < 0.01 vs. placebo). At the same time, ANP induced lipolysis systemically (P < 0.05 vs. placebo) and locally in subcutaneous abdominal adipose tissue (P < 0.0001 vs. placebo), leading to a 50% increase in venous glycerol (P < 0.01) and FFA (P < 0.05) concentrations compared with placebo. The increase in FFA availability with ANP was paralleled by a 15% increase in lipid oxidation rates (P < 0.05 vs. placebo), driving a substantial increase in postprandial energy expenditure (P < 0.05 vs. placebo). CONCLUSIONS-Our data identify the ANP system as a novel pathway regulating postprandial lipid oxidation, energy expenditure, and concomitantly arterial blood pressure. The findings could have therapeutic implications.
Keywords:	Adipose Tissue, Atrial Natriuretic Factor, Blood Flow Velocity, Blood Pressure, Energy Metabolism, Intravenous Infusions, Lipids, Lipolysis, Microdialysis, Oxidation-Reduction, Postprandial Period, Reference Values
Source:	Diabetes
ISSN:	0012-1797
Publisher:	American Diabetes Association
Volume:	57
Number:	12
Page Range:	3199-3204
Date:	December 2008
Official Publication:	https://doi.org/10.2337/db08-0649
PubMed:	View item in PubMed

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