Browse by Research Team

2024

CD3 aptamers promote expansion and persistence of tumor-reactive T cells for adoptive T cell therapy in cancer.
Menon, A.P., Villanueva, H., Meraviglia-Crivelli, D., van Santen, H.M., Hellmeier, J., Zheleva, A., Nonateli, F., Peters, T., Wachsmann, T.L.A., Hernandez-Rueda, M., Huppa, J.B., Schütz, G.J., Sevcsik, E., Moreno, B. and Pastor, F.
Molecular Therapy Nucleic Acids 35 (2): 102198. 11 June 2024

Breakthrough infections in SARS-CoV-2-vaccinated multiple myeloma patients improve cross-protection against omicron variants.
Wagner, A., Garner-Spitzer, E., Auer, C., Gattinger, P., Zwazl, I., Platzer, R., Orola-Taus, M., Pichler, P., Amman, F., Bergthaler, A., Huppa, J.B., Stockinger, H., Zielinski, C.C., Valenta, R., Kundi, M. and Wiedermann, U.
Vaccines 12 (5): 518. 9 May 2024

Measurement of forces acting on single T-cell receptors.
Schrangl, L., Göhring, J., Kellner, F., Huppa, J.B. and Schütz, G.J.
In: Imaging cell signaling. Methods in Molecular Biology, 2800 . Humana New York, NY, New York, NY, USA, 147-165. ISBN 978-1-0716-3834-7 7 May 2024

CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition.
Andreu-Saumell, I., Rodriguez-Garcia, A., Mühlgrabner, V., Gimenez-Alejandre, M., Marzal, B., Castellsagué, J., Brasó-Maristany, F., Calderon, H., Angelats, L., Colell, S., Nuding, M., Soria-Castellano, M., Barbao, P., Prat, A., Urbano-Ispizua, A., Huppa, J.B. and Guedan, S.
Nature Communications 15 (1): 3552. 26 April 2024

Gauging antigen recognition by human primary T-cells featuring orthotopically exchanged TCRs of choice.
Mühlgrabner, V., Plach, A., Holler, J., Leitner, J., Steinberger, P., Dupré, L., Göhring, J. and Huppa, J.B.
Methods in Cell Biology 15 April 2024 (In Press)

CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation.
Eitler, J., Rackwitz, W., Wotschel, N., Gudipati, V., Murali Shankar, N., Sidorenkova, A., Huppa, J.B., Ortiz-Montero, P., Opitz, C., Künzel, S.R., Michen, S., Temme, A., Loureiro, L.R., Feldmann, A., Bachmann, M., Boissel, L., Klingemann, H., Wels, W.S. and Tonn, T.
Journal for ImmunoTherapy of Cancer 12 (2): e008155. 27 February 2024

2023

Harnessing CD3 diversity to optimize CAR T cells.
Velasco Cárdenas, R.M.H., Brandl, S.M., Meléndez, A.V., Schlaak, A.E., Buschky, A., Peters, T., Beier, F., Serrels, B., Taromi, S., Raute, K., Hauri, S., Gstaiger, M., Lassmann, S., Huppa, J.B., Boerries, M., Andrieux, G., Bengsch, B., Schamel, W.W. and Minguet, S.
Nature Immunology 24 (12): 2135-2149. December 2023

Monomeric agonist peptide/MHCII complexes activate T-cells in an autonomous fashion.
Platzer, R., Hellmeier, J., Göhring, J., Perez, I.D., Schatzlmaier, P., Bodner, C., Focke-Tejkl, M., Schütz, G.J., Sevcsik, E., Stockinger, H., Brameshuber, M. and Huppa, J.B.
EMBO Reports 24 (11): e57842. 6 November 2023

Lower magnitude and faster waning of antibody responses to SARS-CoV-2 vaccination in anti-TNF-α-treated IBD patients are linked to lack of activation and expansion of cTfh1 cells and impaired B memory cell formation.
Garner-Spitzer, E., Wagner, A., Gudipati, V., Schoetta, A.M., Orola-Taus, M., Kundi, M., Kunert, R., Mayrhofer, P., Huppa, J.B., Stockinger, H., Carsetti, R., Gattinger, P., Valenta, R., Kratzer, B., Sehgal, A.N.A., Pickl, W.F., Reinisch, W., Novacek, G. and Wiedermann, U.
EBioMedicine 96 : 104788. October 2023

Systemic inflammation and normocytic anemia in DOCK11 deficiency.
Block, J., Rashkova, C., Castanon, I., Zoghi, S., Platon, J., Ardy, R.C., Fujiwara, M., Chaves, B., Schoppmeyer, R., van der Made, C.I., Jimenez Heredia, R., Harms, F.L., Alavi, S., Alsina, L., Sanchez Moreno, P., Ávila Polo, R., Cabrera-Pérez, R., Kostel Bal, S., Pfajfer, L., Ransmayr, B., Mautner, A.K., Kondo, R., Tinnacher, A., Caldera, M., Schuster, M., Domínguez Conde, C., Platzer, R., Salzer, E., Boyer, T., Brunner, H.G., Nooitgedagt-Frons, J.E., Iglesias, E., Deyà-Martinez, A., Camacho-Lovillo, M., Menche, J., Bock, C., Huppa, J.B., Pickl, W.F., Distel, M., Yoder, J.A., Traver, D., Engelhardt, K.R., Linden, T., Kager, L., Hannich, J.T., Hoischen, A., Hambleton, S., Illsinger, S., Da Costa, L., Kutsche, K., Chavoshzadeh, Z., van Buul, J.D., Antón, J., Calzada-Hernández, J., Neth, O., Viaud, J., Nishikimi, A., Dupré, L. and Boztug, K.
New England Journal of Medicine 389 (6): 527-539. 10 August 2023

A DNA origami-based biointerface to interrogate the spatial requirements for sensitized T-Cell antigen recognition.
Hellmeier, J., Platzer, R., Huppa, J.B. and Sevcsik, E.
Methods in Molecular Biology 2654 : 277-302. 28 April 2023

Linoleic acid potentiates CD8(+) T cell metabolic fitness and antitumor immunity.
Nava Lauson, C.B., Tiberti, S., Corsetto, P.A., Conte, F., Tyagi, P., Machwirth, M., Ebert, S., Loffreda, A., Scheller, L., Sheta, D., Mokhtari, Z., Peters, T., Raman, A.T., Greco, F., Rizzo, A.M., Beilhack, A., Signore, G., Tumino, N., Vacca, P., McDonnell, L.A., Raimondi, A., Greenberg, P.D., Huppa, J.B., Cardaci, S., Caruana, I., Rodighiero, S., Nezi, L. and Manzo, T.
Cell Metabolism 35 (4): 633-650.e9. 4 April 2023

T-cell antigen recognition: catch-as-catch-can or catch-22?
Huppa, J.B. and Schütz, G.J.
EMBO Journal 42 (7): e113507. 3 April 2023

Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells.
Horkova, V., Drobek, A., Paprckova, D., Niederlova, V., Prasai, A., Uleri, V., Glatzova, D., Kraller, M., Cesnekova, M., Janusova, S., Salyova, E., Tsyklauri, O., Kadlecek, T.A., Krizova, K., Platzer, R., Schober, K., Busch, D.H., Weiss, A., Huppa, J.B. and Stepanek, O.
Nature Immunology 24 (1): 174-185. January 2023

Mechanistic insights into T-Cell antigen recognition through single molecule microscopy.
Huppa, J.B. and Schütz, G.J.
In: Encyclopedia of Cell Biology. Encyclopedia of Cell Biology . Elsevier, 536-552. ISBN 978-0-12-821624-8 2023

2022

Mechanosurveillance: Tiptoeing T cells.
Göhring, J., Schrangl, L., Schütz, G.J. and Huppa, J.B.
Frontiers in Immunology 13 : 886328. 26 May 2022

Time 2EVOLVE: predicting efficacy of engineered T-cells - how far is the bench from the bedside?
Guedan, S., Luu, M., Ammar, D., Barbao, P., Bonini, C., Bousso, P., Buchholz, C.J., Casucci, M., De Angelis, B., Donnadieu, E., Espie, D., Greco, B., Groen, R., Huppa, J.B., Kantari-Mimoun, C., Laugel, B., Mantock, M., Markman, J.L., Morris, E., Quintarelli, C., Rade, M., Reiche, K., Rodriguez-Garcia, A., Rodriguez-Madoz, J.R., Ruggiero, E., Themeli, M., Hudecek, M. and Marchiq, I.
Journal for ImmunoTherapy of Cancer 10 (5): e003487. May 2022

SARS-CoV-2-specific antibody (Ab) levels and the kinetic of ab decline determine Ab persistence over 1 year.
Garner-Spitzer, E., Wagner, A., Kundi, M., Stockinger, H., Ohradanova-Repic, A., Gebetsberger, L., Schoetta, A.M., Gudipati, V., Huppa, J.B., Kunert, R., Mayrhofer, P., Kreil, T.R., Farcet, M.R., Hoeltl, E. and Wiedermann, U.
Frontiers in Medicine 9 : 822316. 15 February 2022

The frequency of differentiated CD3(+)CD27(-)CD28(-) T cells predicts response to CART cell therapy in diffuse large B-cell lymphoma.
Worel, N., Grabmeier-Pfistershammer, K., Kratzer, B., Schlager, M., Tanzmann, A., Rottal, A., Körmöczi, U., Porpaczy, E., Staber, P.B., Skrabs, C., Herkner, H., Gudipati, V., Huppa, J.B., Salzer, B., Lehner, M., Saxenhuber, N., Friedberg, E., Wohlfarth, P., Hopfinger, G., Rabitsch, W., Simonitsch-Klupp, I., Jäger, U. and Pickl, W.F.
Frontiers in Immunology 13 : 1004703. 9 January 2022

2021

Automated two-dimensional spatiotemporal analysis of mobile single-molecule FRET probes.
Schrangl, L., Göhring, J., Kellner, F., Huppa, J.B. and Schütz, G.J.
Journal of Visualized Experiments 177 : e63124. 23 November 2021

Automated two-dimensional spatiotemporal analysis of mobile single-molecule FRET probes.
Schrangl, L., Göhring, J., Kellner, F., Huppa, J.B. and Schütz, G.J.
[Video] 23 November 2021

Three-dimensional single molecule localization microscopy reveals the topography of the immunological synapse at isotropic precision below 15 nm.
Velas, L., Brameshuber, M., Huppa, J.B., Kurz, E., Dustin, M.L., Zelger, P., Jesacher, A. and Schütz, G.J.
Nano letters 21 (21): 9247-9255. 10 November 2021

2004

CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse.
Li, Q.J., Dinner, A.R., Qi, S., Irvine, D.J., Huppa, J.B., Davis, M.M. and Chakraborty, A.K.
Nature Immunology 5 (8): 791-9. 1 August 2004

Quantitative analysis of lymphocyte membrane protein redistribution from fluorescence microscopy.
Kasson, P.M., Huppa, J.B., Davis, M.M. and Brunger, A.T.
In: International Conference on Image Processing, ICIP 2004, 18-21 Oct 2004. 2004

Quantitative analysis of membrane protein localization and signaling.
Kasson, P.M., Huppa, J.B., Davis, M.M. and Brunger, A.T.
In: IEEE Computational Systems Bioinformatics Conference, CSB 20041, 16-19 Aug 2004. 2004