Browse by Research Team

Article

Targeting cAMP signaling compartments in iPSC-derived models of cardiovascular disease.
Liu, T. and Klussmann, E.
Current Opinion in Pharmacology 71 : 102392. August 2023

Integrated proteomics unveils nuclear PDE3A2 as a regulator of cardiac myocyte hypertrophy.
Subramaniam, G., Schleicher, K., Kovanich, D., Zerio, A., Folkmanaite, M., Chao, Y.C., Surdo, N.C., Koschinski, A., Hu, J., Scholten, A., Heck, A.J.R, Ercu, M., Sholokh, A., Chan Park, K., Klussmann, E., Meraviglia, V., Bellin, M., Zanivan, S., Hester, S., Mohammed, S. and Zaccolo, M.
Circulation Research 132 (7): 828-848. 31 March 2023

Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage.
Ercu, M., Mücke, M.B., Pallien, T., Markó, L., Sholokh, A., Schächterle, C., Aydin, A., Kidd, A., Walter, S., Esmati, Y., McMurray, B.J., Lato, D.F., Sunaga-Franze, D.Y., Dierks, P.H., Flores, B.I.M., Walker-Gray, R., Gong, M., Merticariu, C., Zühlke, K., Russwurm, M., Liu, T., Batolomaeus, T.U.P., Pautz, S., Schelenz, S., Taube, M., Napieczynska, H., Heuser, A., Eichhorst, J., Lehmann, M., Miller, D.C., Diecke, S., Qadri, F., Popova, E., Langanki, R., Movsesian, M.A., Herberg, F.W., Forslund, S.K., Müller, D.N., Borodina, T., Maass, P.G., Bähring, S., Hübner, N., Bader, M. and Klussmann, E.
Circulation 146 (23): 1758-1778. 6 December 2022

Aurora kinase A is involved in controlling the localization of aquaporin-2 in renal principal cells.
Baltzer, S., Bulatov, T., Schmied, C., Krämer, A., Berger, B.T., Oder, A., Walker-Gray, R., Kuschke, C., Zühlke, K., Eichhorst, J., Lehmann, M., Knapp, S., Weston, J., von Kries, J.P., Süssmuth, R.D. and Klussmann, E.
International Journal of Molecular Sciences 23 (2): 763. 11 January 2022

AKAP18δ anchors and regulates CaMKII activity at phospholamban-SERCA2 and RYR.
Carlson, C.R., Aronsen, J.M., Bergan-Dahl, A., Moutty, M.C., Lunde, M., Lunde, P.K., Jarstadmarken, H., Wanichawan, P., Pereira, L., Kolstad, T.R.S., Dalhus, B., Subramanian, H., Hille, S., Christensen, G., Müller, O.J., Nikolaev, V., Bers, D.M., Sjaastad, I., Shen, X., Louch, W.E., Klussmann, E. and Sejersted, O.M.
Circulation Research 130 (1): 27-44. 7 January 2022

Disruptors of AKAP-dependent protein-protein interactions.
Walker-Gray, R., Pallien, T., Miller, D.C., Oder, A., Neuenschwander, M., von Kries, J.P., Diecke, S. and Klussmann, E.
Methods in Molecular Biology 2483 : 117-139. 2022

Reconstitution of β-adrenergic regulation of Ca(V)1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.
Katz, M., Subramaniam, S., Chomsky-Hecht, O., Tsemakhovich, V., Flockerzi, V., Klussmann, E., Hirsch, J.A., Weiss, S. and Dascal, N.
Proceedings of the National Academy of Sciences of the United States of America 118 (21): e2100021118. 17 May 2021

Improving target assessment in biomedical research: the GOT-IT recommendations.
Emmerich, C.H., Gamboa, L.M., Hofmann, M.C.J., Bonin-Andresen, M., Arbach, O., Schendel, P., Gerlach, B., Hempel, K., Bespalov, A., Dirnagl, U. and Parnham, M.J.
Nature Reviews Drug Discovery 20 (1): 64-81. January 2021

Phosphodiesterase 3A and arterial hypertension.
Ercu, M., Markó, L., Schächterle, C., Tsvetkov, D., Cui, Y., Maghsodi, S., Bartolomaeus, T.U.P., Maass, P.G., Zühlke, K., Gregersen, N., Hübner, N., Hodge, R., Mühl, A., Pohl, B., Molé-Illas, R., Geelhaar, A., Walter, S., Napieczynska, H., Schelenz, S., Taube, M., Heuser, A., Anistan, Y.M., Qadri, F., Todiras, M., Plehm, R., Popova, E., Langanki, R., Eichhorst, J., Lehmann, M., Wiesner, B., Russwurm, M., Forslund, S.K., Kamer, I., Müller, D.N., Gollasch, M., Aydin, A., Bähring, S., Bader, M., Luft, F.C. and Klussmann, E.
Circulation 142 (2): 133-149. 14 July 2020

Cyclin-dependent kinase 18 controls trafficking of aquaporin-2 and its abundance through ubiquitin ligase STUB1, which functions as an AKAP.
Dema, A., Faust, D., Lazarow, K., Wippich, M., Neuenschwander, M., Zühlke, K., Geelhaar, A., Pallien, T., Hallscheidt, E., Eichhorst, J., Wiesner, B., Cernecká, H., Popp, O., Mertins, P., Dittmar, G., von Kries, J.P. and Klussmann, E.
Cells 9 (3): 673. 10 March 2020

Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1.
Zhao, X., Nedvetsky, P., Stanchi, F., Vion, A.C., Popp, O., Zühlke, K., Dittmar, G., Klussmann, E. and Gerhardt, H.
eLife 8 : e46380. 3 October 2019

Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases.
Omar, F., Findlay, J.E., Carfray, G., Allcock, R.W., Jiang, Z., Moore, C., Muir, A.L., Lannoy, M., Fertig, B.A., Mai, D., Day, J.P., Bolger, G., Baillie, G.S., Schwiebert, E., Klussmann, E., Pyne, N.J., Ong, A.C.M., Bowers, K., Adam, J.M., Adams, D.R., Houslay, M.D. and Henderson, D.J.P.
Proceedings of the National Academy of Sciences of the United States of America 116 (27): 13320-13329. 2 July 2019

Fluconazole increases osmotic water transport in renal collecting duct through effects on aquaporin-2 trafficking.
Vukićević, T., Hinze, C., Baltzer, S., Himmerkus, N., Quintanova, C., Zühlke, K., Compton, F., Ahlborn, R., Dema, A., Eichhorst, J., Wiesner, B., Bleich, M., Schmidt-Ott, K.M. and Klussmann, E.
Journal of the American Society of Nephrology 30 (5): 795-810. May 2019

Anoctamin-4 is a bona fide Ca(2+)-dependent non-selective cation channel.
Reichhart, N., Schöberl, S., Keckeis, S., Alfaar, A.S., Roubeix, C., Cordes, M., Crespo-Garcia, S., Haeckel, A., Kociok, N., Föckler, R., Fels, G., Mataruga, A., Rauh, R., Milenkovic, V.M., Zühlke, K., Klussmann, E., Schellenberger, E. and Strauß, O.
Scientific Reports 9 (1): 2257. 19 February 2019

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.
Campa, C.C., Silva, R.L., Margaria, J.P., Pirali, T., Mattos, M.S., Kraemer, L.R., Reis, D.C., Grosa, G., Copperi, F., Dalmarco, E.M., Lima-Júnior, R.C.P., Aprile, S., Sala, V., Dal Bello, F., Prado, D.S., Alves-Filho, J.C., Medana, C., Cassali, G.D., Tron, G.C., Teixeira, M.M., Ciraolo, E., Russo, R.C. and Hirsch, E.
Nature Communications 9 (1): 5232. 12 December 2018

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.
Schrade, K., Tröger, J., Eldahshan, A., Zühlke, K., Abdul Azeez, K.R., Elkins, J.M., Neuenschwander, M., Oder, A., Elkewedi, M.M.H., Jaksch, S., Andrae, K., Li, J., Fernandes, J., Müller, P.M., Grunwald, S., Marino, S.F., Vukićević, T., Eichhorst, J., Wiesner, B., Weber, M., Kapiloff, M., Rocks, O., Daumke, O., Wieland, T., Knapp, S., von Kries, J.P. and Klussmann, E.
PLoS ONE 13 (1): e0191423. 26 January 2018

Protein kinase C enhances plasma membrane expression of cardiac L-type calcium channel, Ca(V)1.2.
Raifman, T.K., Kumar, P., Haase, H., Klussmann, E., Dascal, N. and Weiss, S.
Channels 11 (6): 604-615. 2 November 2017

Protein kinase A regulates C-terminally truncated Ca(V) 1.2 in Xenopus oocytes: roles of N- and C-termini of the α(1C) subunit.
Oz, S., Pankonien, I., Belkacemi, A., Flockerzi, V., Klussmann, E., Haase, H. and Dascal, N.
Journal of Physiology 595 (10): 3181-3202. 15 May 2017

Bimodal antagonism of PKA signalling by ARHGAP36.
Eccles, R.L., Czajkowski, M.T., Barth, C., Müller, P.M., McShane, E., Grunwald, S., Beaudette, P., Mecklenburg, N., Volkmer, R., Zühlke, K., Dittmar, G., Selbach, M., Hammes, A., Daumke, O., Klussmann, E., Urbé, S. and Rocks, O.
Nature Communications 7 : 12963. 7 October 2016

The A-kinase anchoring protein (AKAP) glycogen synthase kinase 3β interaction protein (GSKIP) regulates β-catenin through its interactions with both protein kinase A (PKA) and GSK3β.
Dema, A., Schröter, M.F., Perets, E., Skroblin, P., Moutty, M.C., Deàk, V.A., Birchmeier, W. and Klussmann, E.
Journal of Biological Chemistry 291 (37): 19618-19630. 9 September 2016

Pharmacological interference with protein-protein interactions of A-kinase anchoring proteins as a strategy for the treatment of disease.
Deák, V.A. and Klussmann, E.
Current Drug Targets 17 (10): 1147-1171. 1 August 2016

AKAP18:PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA.
Götz, F., Roske, Y., Schulz, M.S., Autenrieth, K., Bertinetti, D., Faelber, K., Zühlke, K., Kreuchwig, A., Kennedy, E., Krause, G., Daumke, O., Herberg, F.W., Heinemann, U. and Klussmann, E.
Biochemical Journal 473 (13): 1881-1894. 28 June 2016

The A-kinase anchoring protein GSKIP regulates GSK3β activity and controls palatal shelf fusion in mice.
Deák, V.A., Skroblin, P., Dittmayer, C., Knobeloch, K.P., Bachmann, S. and Klussmann, E.
Journal of Biological Chemistry 291 (2): 681-690. 8 January 2016

Clinical effects of phosphodiesterase 3A mutations in inherited hypertension with brachydactyly.
Toka, O., Tank, J., Schächterle, C., Aydin, A., Maass, P.G., Elitok, S., Bartels-Klein, E., Hollfinger, I., Lindschau, C., Mai, K., Boschmann, M., Rahn, G., Movsesian, M.A., Müller, T., Doescher, A., Gnoth, S., Mühl, A., Toka, H.R., Wefeld-Neuenfeld, Y., Utz, W., Töpper, A., Jordan, J., Schulz-Menger, J., Klussmann, E., Bähring, S. and Luft, F.C.
Hypertension 66 (4): 800-808. October 2015

Neurochondrin is an atypical RIIα-specific A-kinase anchoring protein.
Hermann, J.S., Skroblin, P., Bertinetti, D., Hanold, L.E., von der Heide, E.K., Wagener, E.M., Zenn, H.M., Klussmann, E., Kennedy, E.J. and Herberg, F.W.
Biochimica et Biophysica Acta - Proteins and Proteomics 1854 (10 Pt B): 1667-1675. October 2015

PDE3A mutations cause autosomal dominant hypertension with brachydactyly.
Maass, P.G., Aydin, A., Luft, F.C., Schächterle, C., Weise, A., Stricker, S., Lindschau, C., Vaegler, M., Qadri, F., Toka, H.R., Schulz, H., Krawitz, P.M., Parkhomchuk, D., Hecht, J., Hollfinger, I., Wefeld-Neuenfeld, Y., Bartels-Klein, E., Mühl, A., Kann, M., Schuster, H., Chitayat, D., Bialer, M.G., Wienker, T.F., Ott, J., Rittscher, K., Liehr, T., Jordan, J., Plessis, G., Tank, J., Mai, K., Naraghi, R., Hodge, R., Hopp, M., Hattenbach, L.O., Busjahn, A., Rauch, A., Vandeput, F., Gong, M., Rüschendorf, F., Hübner, N., Haller, H., Mundlos, S., Bilginturan, N., Movsesian, M.A., Klussmann, E., Toka, O. and Bähring, S.
Nature Genetics 47 (6): 647-653. June 2015

A-kinase anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle.
Poppinga, W.J., Heijink, I.H., Holtzer, L.J., Skroblin, P., Klussmann, E., Halayko, A.J., Timens, W., Maarsingh, H. and Schmidt, M.
American Journal of Physiology Lung Cellular and Molecular Physiology 308 (8): L766-L775. 15 April 2015

Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains.
Bolger, G.B., Dunlop, A.J., Meng, D., Day, J.P., Klussmann, E., Baillie, G.S., Adams, D.R. and Houslay, M.D.
Cellular Signalling 27 (4): 756-769. April 2015

Regulation of sarcoplasmic reticulum Ca(2+) ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2.
Ahmad, F., Shen, W., Vandeput, F., Szabo-Fresnais, N., Krall, J., Degerman, E., Goetz, F., Klussmann, E., Movsesian, M. and Manganiello, V.
Journal of Biological Chemistry 290 (11): 6763-6776. 13 March 2015

Screening for small molecule disruptors of AKAP-PKA interactions.
Schächterle, C., Christian, F., Fernandes, J.M.P. and Klussmann, E.
Methods in Molecular Biology 1294 : 151-166. 2 March 2015

Keeping those telomeres short! an innovative intratumoral long-term drug delivery system.
Laster, B.H., Isaacson, C., Perets, E., Msamra, M., Priel, E., Kalef-Ezra, J. and Kost, J.
Journal of Cancer Research and Clinical Oncology 141 (1): 23-34. January 2015

The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex.
Abdul Azeez, K.R., Knapp, S., Fernandes, J.M.P., Klussmann, E. and Elkins, J.M.
Biochemical Journal 464 (2): 231-239. 1 December 2014

Flexible, polymer-supported synthesis of sphingosine derivatives provides ceramides with enhanced biological activity.
El-Dahshan, A., Al-Gharabli, S.I., Radetzki, S., Al-Tel, T.H., Kumar, P. and Rademann, J.
Bioorganic and Medicinal Chemistry 22 (19): 5506-5512. 1 October 2014

G protein-coupled estrogen receptor 1 (GPER) mediates relaxation of coronary arteries via cAMP/PKA-dependent activation of MLCP.
Yu, X., Li, F., Klussmann, E., Stallone, J.N. and Han, G.
American Journal of Physiology Endocrinology and Metabolism 307 (4): E398-E407. 15 August 2014

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.
Schäfer, G., Milić, J, Eldahshan, A, Götz, F., Zühlke, K., Schillinger, C., Kreuchwig, A., Elkins, J.M., Abdul Azeez, K.R.A., Oder, A., Moutty, M.C., Masada, N., Beerbaum, M., Schlegel, B., Niquet, S., Schmieder, P., Krause, G., von Kries, J.P., Cooper, D.M.F., Knapp, S., Rademann, J., Rosenthal, W. and Klussmann, E.
Angewandte Chemie International Edition 52 (46): 12187-12191. 11 November 2013

AKAPS act in a two-step mechanism of memory acquisition.
Scheunemann, L., Skroblin, P., Hundsrucker, C., Klussmann, E., Efetova, M. and Schwärzel, M.
Journal of Neuroscience 33 (44): 17422-17428. 30 October 2013

Culturing primary rat inner medullary collecting duct cells.
Faust, D., Geelhaar, A., Eisermann, B., Eichhorst, J., Wiesner, B., Rosenthal, W. and Klussmann, E.
Journal of Visualized Experiments (76): e50366. 21 June 2013

Small-molecule screening identifies modulators of aquaporin-2 trafficking.
Bogum, J., Faust, D., Zühlke, K., Eichhorst, J., Moutty, M.C., Furkert, J., Eldahshan, A., Neuenschwander, M., von Kries, J.P., Wiesner, B., Trimpert, C., Deen, P.M., Valenti, G., Rosenthal, W. and Klussmann, E.
Journal of the American Society of Nephrology 24 (5): 744-758. April 2013

Mechanism for targeting the A-kinase anchoring protein AKAP18δ to the membrane.
Horner, A., Goetz, F., Tampe, R., Klussmann, E. and Pohl, P.
Journal of Biological Chemistry 287 (51): 42495-42501. 14 December 2012

A key phosphorylation site in AC8 mediates regulation of Ca2+-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.
Willoughby, D., Halls, M.L., Everett, K.L., Skroblin, P., Klussmann, E. and Cooper, D.M.F.
Journal of Cell Science 125 (Pt 23): 5850-5859. 1 December 2012

Vasopressin increases S261 phosphorylation in AQP2-P262L, a mutant in recessive nephrogenic diabetes insipidus.
Trimpert, C., van den Berg, D.T.M., Fenton, R.A., Klussmann, E. and Deen, P.M.T.
Nephrology Dialysis Transplantation 27 (12): 4389-4397. December 2012

The protease-activated receptor 1 possesses a functional and cleavable signal peptide which is necessary for receptor expression.
Zampatis, D.E., Rutz, C., Furkert, J., Schmidt, A., Wuestenhagen, D., Kubick, S., Tsopanoglou, N.E. and Schuelein, R.
FEBS Letters 586 (16): 2351-2359. 31 May 2012

Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling.
Willoughby, D., Everett, K.L., Halls, M.L., Pacheco, J., Skroblin, P., Vaca, L., Klussmann, E. and Cooper, D.M.
Science Signaling 5 (219): ra29. 10 April 2012

Spinophilin regulates central angiotensin II-mediated effect on blood pressure.
da Costa Goncalves, A.C., Fontes, M.A., Klussmann, E., Qadri, F., Janke, J., Gollasch, M., Schleifenbaum, J., Mueller, D., Jordan, J., Tank, J., Luft, F.C. and Gross, V.
Journal of Molecular Medicine 89 (12): 1219-1229. December 2011

Inhibition of the biosynthesis of the human endothelin B receptor by the cyclodepsipeptide cotransin.
Westendorf, C., Schmidt, A., Coin, I., Furkert, J., Ridelis, I., Zampatis, D., Rutz, C., Wiesner, B., Rosenthal, W., Beyermann, M. and Schuelein, R.
Journal of Biological Chemistry 286 (41): 35588-35600. 14 October 2011

Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.
Murdoch, H., Vadrevu, S., Prinz, A., Dunlop, A.J., Klussmann, E., Bolger, G.B., Norman, J.C. and Houslay, M.D.
Journal of Cell Science 124 (Pt 13): 2253-2266. 1 July 2011

Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4).
Day, J.P., Lindsay, B., Riddell, T., Jiang, Z., Allcock, R.W., Abraham, A., Sookup, S., Christian, F., Bogum, J., Martin, E.K., Rae, R.L., Anthony, D., Rosair, G.M., Houslay, D.M., Huston, E., Baillie, G.S., Klussmann, E., Houslay, M.D. and Adams, D.R.
Journal of Medicinal Chemistry 54 (9): 3331-3347. 12 May 2011

Small molecule AKAP/PKA interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes.
Christian, F., Szaszak, M., Friedl, S., Drewianka, S., Lorenz, D., Goncalves, A., Furkert, J., Vargas, C., Schmieder, P., Goetz, F., Zuehlke, K., Moutty, M., Goettert, H., Joshi, M., Reif, B., Haase, H., Morano, I., Grossmann, S., Klukovits, A., Verli, J., Gaspar, R., Noack, C., Bergmann, M., Kass, R., Hampel, K., Kashin, D., Genieser, H.G., Herberg, F.W., Willoughby, D., Cooper, D.M., Baillie, G.S., Houslay, M.D., von Kries, J.P., Zimmermann, B., Rosenthal, W. and Klussmann, E.
Journal of Biological Chemistry 286 (11): 9079-9096. 18 March 2011

Routes of epithelial water flow: aquaporins versus cotransporters.
Mollajew, R., Zocher, F., Horner, A., Wiesner, B., Klussmann, E. and Pohl, P.
Biophysical Journal 99 (11): 3647-3656. 1 December 2010

The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activity.
Schulz, K., Rutz, C., Westendorf, C., Ridelis, I., Vogelbein, S., Furkert, J., Schmidt, A., Wiesner, B. and Schuelein, R.
Journal of Biological Chemistry 285 (43): 32878-32887. 22 October 2010

Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase.
Nedvetsky, P.I., Tabor, V., Tamma, G., Beulshausen, S., Skroblin, P., Kirschner, A., Mutig, K., Boltzen, M., Petrucci, O., Vossenkaemper, A., Wiesner, B., Bachmann, S., Rosenthal, W. and Klussmann, E.
Journal of the American Society of Nephrology 21 (10): 1645-1656. October 2010

Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.
Li, X., Vadrevu, S., Dunlop, A., Day, J., Advant, N., Troeger, J., Klussmann, E., Jaffrey, E., Hay, R.T., Adams, D.R., Houslay, M.D. and Baillie, G.S.
Biochemical Journal 428 (1): 55-65. 15 May 2010

Glycogen synthase kinase 3β interaction protein functions as an A-kinase anchoring protein.
Hundsrucker, C., Skroblin, P., Christian, F., Zenn, M., Popara, V., Joshi, M., Eichhorst, J., Wiesner, B., Herberg, F.W., Reif, B., Rosenthal, W. and Klussmann, E.
Journal of Biological Chemistry 285 (8): 5507-5521. 19 February 2010

MEK1 binds directly to βarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.
Meng, D., Lynch, M.J., Huston, E., Beyermann, M., Eichhorst, J., Adams, D.R., Klussmann, E., Houslay, M.D. and Baillie, G.S.
Journal of Biological Chemistry 284 (17): 11425-1135. 24 April 2009

1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1.
Smith, K.J., Baillie, G.S., Hyde, E.I., Li, X., Houslay, T.M., McCahill, A., Dunlop, A.J., Bolger, G.B., Klussmann, E., Adams, D.R. and Houslay, M.D.
Cellular Signalling 19 (12): 2612-2624. December 2007

AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum.
Lygren, B., Carlson, C.R., Santamaria, K., Lissandron, V., McSorley, T., Litzenberg, J., Lorenz, D., Wiesner, B., Rosenthal, W., Zaccolo, M., Tasken, K. and Klussmann, E.
EMBO Reports 8 (11): 1061-1067. 1 November 2007

Microtubules are needed for the perinuclear positioning of aquaporin-2 after its endocytic retrieval in renal principal cells.
Vossenkaemper, A., Nedvetsky, P.I., Wiesner, B., Furkert, J., Rosenthal, W. and Klussmann, E.
American Journal of Physiology Cell Physiology 293 (3): C1129-C1138. 11 September 2007

Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.
Murdoch, H., Mackie, S., Collins, D.M., Hill, E.V., Bolger, G.B., Klussmann, E., Porteous, D.J., Millar, J.K. and Houslay, M.D.
Journal of Neuroscience 27 (35): 9513-9524. 29 August 2007

p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway.
Sachs, B.D., Baillie, G.S., McCall, J.R., Passino, M.A., Schachtrup, C., Wallace, D.A., Dunlop, A.J., MacKenzie, K.F., Klussmann, E., Lynch, M.J., Sikorski, S.L., Nuriel, T., Tsigelny, I., Zhang, J., Houslay, M.D., Chao, M.V. and Akassoglou, K.
Journal of Cell Biology 177 (6): 1119-1132. 18 June 2007

Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays.
Baillie, G.S., Adams, D.R., Bhari, N., Houslay, T.M., Vadrevu, S., Meng, D., Li, X., Dunlop, A., Milligan, G., Bolger, G.B., Klussmann, E. and Houslay, M.D.
Biochemical Journal 404 (1): 71-80. 15 May 2007

A role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle.
Nedvetsky, P.I., Stefan, E., Frische, S., Santamaria, K., Wiesner, B., Valenti, G., Hammer, J.A., Nielsen, S., Goldenring, J.R., Rosenthal, W. and Klussmann, E.
Traffic 8 (2): 110-123. February 2007

Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.
Stefan, E., Wiesner, B., Baillie, G.S., Mollajew, R., Henn, V., Lorenz, D., Furkert, J., Santamaria, K., Nedvetsky, P.I., Hundsrucker, C., Beyermann, M., Krause, E., Pohl, P., Gall, I., MacIntyre, A.N., Bachmann, S., Houslay, M.D., Rosenthal, W. and Klussmann, E.
Journal of the American Society of Nephrology 18 (1): 199-212. January 2007

Protein-Protein-Interaktionen als Ziel fuer neue Pharmaka : EU-Projekt thera-cAMP.
Klussmann, E.
BIOforum 2 : 32-34. 2007

Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.
Bolger, G.B., Baillie, G.S., Li, X., Lynch, M.J., Herzyk, P., Mohamed, A., Mitchell, L.H., McCahill, A., Hundsrucker, C., Klussmann, E., Adams, D.R. and Houslay, M.D.
Biochemical Journal 398 (1): 23-36. 15 August 2006

Peptides for disruption of PKA anchoring.
Hundsrucker, C., Rosenthal, W. and Klussmann, E.
Biochemical Society Transactions 34 (Pt 4): 472-473. 1 August 2006

Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells.
McSorley, T., Stefan, E., Henn, V., Wiesner, B., Baillie, G.S., Houslay, M.D., Rosenthal, W. and Klussmann, E.
European Journal of Cell Biology 85 (7): 673-678. 5 July 2006

High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides.
Hundsrucker, C., Krause, G., Beyermann, M., Prinz, A., Zimmermann, B., Diekmann, O., Lorenz, D., Stefan, E., Nedvetsky, P., Dathe, M., Christian, F., McSorley, T., Krause, E., McConnachie, G., Herberg, F.W., Scott, J.D., Rosenthal, W. and Klussmann, E.
Biochemical Journal 396 (2): 297-306. 1 June 2006

Compartmentalized cAMP signalling regulates vasopressin-mediated water reabsorption by controlling aquaporin-2.
Henn, V., Stefan, E., Baillie, G.S., Houslay, M.D., Rosenthal, W. and Klussmann, E.
Biochemical Society Transactions 33 (Pt 6): 1316-1318. December 2005

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.
Lynch, M.J., Baillie, G.S., Mohamed, A., Li, X., Maisonneuve, C., Klussmann, E., van Heeke, G. and Houslay, M.D.
Journal of Biological Chemistry 280 (39): 33178-33189. 30 September 2005

Actin remodeling requires ERM function to facilitate AQP2 apical targeting.
Tamma, G., Klussmann, E., Oehlke, J., Krause, E., Rosenthal, W., Svelto, M. and Valenti, G.
Journal of Cell Science 118 (Pt 16): 3623-3630. 15 August 2005

Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells.
Henn, V., Edemir, B., Stefan, E., Wiesner, B., Lorenz, D., Theilig, F., Schmitt, R., Vossebein, L., Tamma, G., Beyermann, M., Krause, E., Herberg, F.W., Valenti, G., Bachmann, S., Rosenthal, W. and Klussmann, E.
Journal of Biological Chemistry 279 (25): 26654-26665. 18 June 2004

The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho.
Tamma, G., Wiesner, B., Furkert, J., Hahm, D., Oksche, A., Schaefer, M., Valenti, G., Rosenthal, W. and Klussmann, E.
Journal of Cell Science 116 (Pt 16): 3285-3294. 15 August 2003

Renal expression of sodium transporters and aquaporin-2 in hypothyroid rats.
Schmitt, R., Klussmann, E., Kahl, T., Ellison, D.H. and Bachmann, S.
American Journal of Physiology Renal Physiology 284 (5): F1097-F1104. May 2003

cAMP-induced AQP2 translocation is associated with RhoA inhibition through RhoA phosphorylation and interaction with RhoGDI.
Tamma, G., Klussmann, E., Procino, G., Svelto, M., Rosenthal, W. and Valenti, G.
Journal of Cell Science 116 (Pt 8): 1519-1525. 15 April 2003

Osmolality and solute composition are strong regulators of AQP2 expression in renal principal cells.
Storm, R., Klussmann, E., Geelhaar, A., Rosenthal, W. and Maric, K.
American Journal of Physiology Renal Physiology 284 (1): F189-F198. January 2003

Rho inhibits cAMP-induced translocation of aquaporin-2 into the apical membrane of renal cells.
Tamma, G., Klussmann, E., Maric, K., Aktories, K., Svelto, M., Rosenthal, W. and Valenti, G.
American Journal of Physiology Renal Physiology 281 (6): F1092-F1101. December 2001

Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling.
Klussmann, E., Edemir, B., Pepperle, B., Tamma, G., Henn, V., Klauschenz, E., Hundsrucker, C., Maric, K. and Rosenthal, W.
FEBS Letters 507 (3): 264-268. 2 November 2001

Role and identification of protein kinase A anchoring proteins in vasopressin-mediated aquaporin-2 translocation.
Klussmann, E. and Rosenthal, W.
Kidney International 60 (2): 446-449. August 2001

An inhibitory role of Rho in the vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells.
Klussmann, E., Tamma, G., Lorenz, D., Wiesner, B., Maric, K., Hofmann, F., Aktories, K., Valenti, G. and Rosenthal, W.
Journal of Biological Chemistry 276 (23): 20451-20457. 8 June 2001

Cell volume kinetics of adherent epithelial cells measured by laser scanning reflection microscopy: determination of water permeability changes of renal principal cells.
Maric, K., Wiesner, B., Lorenz, D., Klussmann, E., Betz, T. and Rosenthal, W.
Biophysical Journal 80 (4): 1783-1790. April 2001

Protein kinase A anchoring proteins are required for vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells.
Klussmann, E., Maric, K., Wiesner, B., Beyermann, M. and Rosenthal, W.
Journal of Biological Chemistry 274 (8): 4934-4938. 19 February 1999

MUC2 gene suppression in human colorectal carcinomas and their metastases: in vitro evidence of the modulatory role of DNA methylation.
Hanski, C., Riede, E., Gratchev, A., Foss, H.D., Boehm, C., Klussmann, E., Hummel, M., Mann, B., Buhr, H.J., Stein, H., Kim, Y.S., Gum, J. and Riecken, E.O.
Laboratory Investigation 77 (6): 685-695. December 1997

Low O-acetylation of sialyl-Le(x) contributes to its overexpression in colon carcinoma metastases.
Mann, B., Klussmann, E., Vandamme-Feldhaus, V., Iwersen, M., Hanski, M.L., Riecken, E.O., Buhr, H.J., Schauer, R., Kim, Y.S. and Hanski, C.
International Journal of Cancer 72 (2): 258-264. 17 July 1997

Fucosyltransferase III and sialyl-Le(x) expression correlate in cultured colon carcinoma cells but not in colon carcinoma tissue.
Hanski, C., Klussmann, E., Wang, J., Boehm, C., Ogorek, D., Hanski, M.L., Krueger-Krasagakes, S., Eberle, J., Schmitt-Graeff, A. and Riecken, E.O.
Glycoconjugate Journal 13 (5): 727-733. October 1996

Expression of MUC2-mucin in colorectal adenomas and carcinomas of different histological types.
Blanke, M., Klussmann, E., Krueger-Krasagakes, S., Schmitt-Graeff, A., Stolte, M., Bornhoeft, G., Stein, H., Xing, P.X., McKenzie, I.F., Verstijnen, C.P., Riecken, E.O. and Hanski, C.
International Journal of Cancer 59 (3): 301-306. 1 November 1994

Altered glycosylation of the MUC-1 protein core contributes to the colon carcinoma-associated increase of mucin-bound sialyl-Lewis(x) expression.
Hanski, C., Drechsler, K., Hanisch, F.G., Sheehan, J., Manske, M., Ogorek, D., Klussmann, E., Hanski, M.L., Blank, M., Xing, P.X., McKenzie, I.F.C., Devine, P.L. and Riecken, E.O.
Cancer Research 53 (17): 4082-4088. 1 September 1993

Book Section

A-kinase anchoring proteins (AKAPs).
Walker-Gray, R. and Klussmann, E.
In: Encyclopedia of Molecular Pharmacology : Third Edition. Springer, Cham, 78-83. ISBN 978-3-030-57400-0 2021

A-kinase anchoring proteins (AKAPs).
Walker-Gray, R. and Klussmann, E.
In: Encyclopedia of Molecular Pharmacology. Springer, Cham, 1-7. ISBN 978-3-030-21573-6 2020

Pharmacological approaches for delineating functions of AKAP- based signalling complexes and finding therapeutic targets.
Schrade, K. and Klussmann, E.
In: Microdomains in the Cardiovascular System. Cardiac and Vascular Biology . Springer, Cham, Switzerland, 59-83. ISBN 978-3-319-54578-3 20 September 2017

Review

Many kinases for controlling the water channel aquaporin‐2.
Kharin, A. and Klussmann, E.
Journal of Physiology 602 (13): 3025-3039. 1 July 2023

Mutations in phosphodiesterase 3A (PDE3A) cause hypertension without cardiac damage.
Ercu, M., Walter, S. and Klussmann, E.
Hypertension 80 (6): 1171-1179. June 2023

Local cyclic adenosine monophosphate signalling cascades - roles and targets in chronic kidney disease.
Sholokh, A. and Klussmann, E.
Acta Physiologica 232 (1): e13641. May 2021

Vasopressin-vermittelte Wasserrückresorption im Sammelrohr der Niere [Vasopressin-mediated water reabsorption in the renal collecting duct].
Baltzer, S. and Klussmann, E.
BIOspektrum 27 (2): 165-167. March 2021

New aspects in cardiac L-type Ca(2+) channel regulation.
Pallien, T. and Klussmann, E.
Biochemical Society Transactions 48 (1): 39-49. February 2020

Small molecules for modulating the localisation of the water channel aquaporin-2-disease relevance and perspectives for targeting local cAMP signalling.
Baltzer, S. and Klussmann, E.
Naunyn-Schmiedeberg's Archives of Pharmacology 392 (9): 1049-1064. September 2019

Roles of A-kinase anchoring proteins and phosphodiesterases in the cardiovascular system.
Ercu, M. and Klussmann, E.
Journal of Cardiovascular Development and Disease 5 (1): 14. 20 February 2018

Protein-protein interactions of PDE4 family members - Functions, interactions and therapeutic value.
Klussmann, E.
Cellular Signalling 28 (7): 713-718. July 2016

The trafficking of the water channel aquaporin-2 in renal principal cells-a potential target for pharmacological intervention in cardiovascular diseases.
Vukićević, T., Schulz, M., Faust, D. and Klussmann, E.
Frontiers in Pharmacology 7 : 23. 11 February 2016

Pharmacological targeting of AKAP-directed compartmentalized cAMP signalling.
Dema, A., Perets, E., Schulz, M.S., Deák, V.A. and Klussmann, E.
Cellular Signalling 27 (12): 2474-2487. December 2015

A-kinase anchoring proteins as potential drug targets.
Troeger, J., Moutty, M.C., Skroblin, P. and Klussmann, E.
British Journal of Pharmacology 166 (2): 420-433. May 2012

Functional significance of cleavable signal peptides of G protein-coupled receptors.
Schuelein, R., Westendorf, C., Krause, G. and Rosenthal, W.
European Journal of Cell Biology 91 (4): 294-299. April 2012

Mechanisms of protein kinase A anchoring.
Skroblin, P., Grossmann, S., Schaefer, G., Rosenthal, W. and Klussmann, E.
International Review of Cell and Molecular Biology 283 (C): 235-330. 2010

Regulation of aquaporin-2 trafficking.
Nedvetsky, P.I., Tamma, G., Beulshausen, S., Valenti, G., Rosenthal, W. and Klussmann, E.
Handbook of Experimental Pharmacology 190 (II): 133-157. 2009

Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells.
Szaszak, M., Christian, F., Rosenthal, W. and Klussmann, E.
Cellular Signalling 20 (4): 590-601. April 2008

Direct AKAP-mediated protein-protein interactions as potential drug targets.
Hundsrucker, C. and Klussmann, E.
Handbook of Experimental Pharmacology 186 : 483-503. 2008

Protein-protein interactions as target for new therapeutic molecules.
Klussmann, E.
BIOforum Europe 3 : 18-19. 2007

AKAP7.
Klussmann, E. and Rosenthal, W.
UCSD Nature Molecule Pages 4 April 2006

The mechanisms of aquaporin control in the renal collecting duct.
Klussmann, E., Maric, K. and Rosenthal, W.
Reviews of Physiology Biochemistry and Pharmacology 141 : 33-95. 2000

Letter

Mutant phosphodiesterase 3A protects the kidney from hypertension-induced damage.
Sholokh, A., Walter, S., Markó, L., McMurray, B.J., Sunaga-Franze, D.Y., Xu, M., Zühlke, K., Russwurm, M., Bartolomaeus, T.U.P., Langanki, R., Qadri, F., Heuser, A., Patzak, A., Forslund, S.K., Bähring, S., Borodina, T., Persson, P.B., Maass, P.G., Bader, M. and Klussmann, E.
Kidney International 104 (2): 388-393. August 2023

A novel AQP2 sequence variant causing aquaporin-2 retention in the cytoplasm and autosomal dominant nephrogenic diabetes insipidus.
Hinrichs, G.R., Baltzer, S., Pallien, T., Svenningsen, P., Dalgaard, E.B., Hertz, J.M., Bistrup, C., Jensen, B.L. and Klussmann, E.
Kidney International Reports 7 (10): 2289-2294. October 2022

Editorial

Aquaporin-2 is not alone.
Klussmann, E.
Kidney International 103 (3): 458-460. March 2023

The role of AKAP12 in coordination of VEGF-induced endothelial cell motility.
Walker-Gray, R. and Klussmann, E.
Acta Physiologica 228 (1): e13359. January 2020

The Case : a handful of hypertension.
van den Born, B.J.H., Oskam, L.C., Zidane, M., Schaechterle, C., Klussmann, E., Bähring, S. and Luft, F.C.
Kidney International 90 (4): 911-913. October 2016

First international meeting on anchored cAMP signaling pathways, Biomedical Campus, Berlin-Buch, Germany, 15-16 October 2005.
Klussmann, E.
European Journal of Cell Biology 85 (7): 581-584. 5 July 2006

Preprint

Wnt11/Fzd7 signaling compartmentalizes AKAP2/PKA to regulate L-type Ca(2+) channel.
Csalyi, K.D., Rharass, T., Schulz, M., Phan, M.H.Q., Wakula, P., Mhatre, K.N., Plotnick, D., Werdich, A.A., Zauber, H., Sury, M.D., Selbach, M., Heinzel, F.R., Klussmann, E. and Panakova, D.
bioRxiv : 741637. 20 August 2019