Browse by Research Team

2020

A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics.
Konrath, F., Mittermeier, A., Cristiano, E., Wolf, J. and Loewer, A.
PLoS Computational Biology 16 (6): e1007901. 26 June 2020

Disentangling pro-mitotic signaling during cell cycle progression using time-resolved single-cell imaging.
Benary, M., Bohn, S., Lüthen, M., Nolis, I.K., Blüthgen, N. and Loewer, A.
Cell Reports 31 (2): 107514. 14 April 2020

2019

PCNA-mediated degradation of p21 coordinates the DNA damage response and cell cycle regulation in individual cells.
Sheng, C., Mendler, I.H., Rieke, S., Snyder, P., Jentsch, M., Friedrich, D., Drossel, B. and Loewer, A.
Cell Reports 27 (1): 48-58. 2 April 2019

Comparing agent‐based delivery of DNA and PNA forced intercalation (FIT) probes for multicolor mRNA imaging.
Chamiolo, J., Fang, G.M., Hövelmann, F., Friedrich, D., Knoll, A., Loewer, A. and Seitz, O.
ChemBioChem 20 (4): 595-604. 15 February 2019

2018

A bright FIT-PNA hybridization probe for the hybridization state specific analysis of a C → U RNA edit via FRET in a binary system.
Fang, G.M., Chamiolo, J., Kankowski, S., Hövelmann, F., Friedrich, D., Löwer, A., Meier, J.C. and Seitz, O.
Chemical Science 9 (21): 4794-4800. 7 June 2018

Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels.
Strasen, J., Sarma, U., Jentsch, M., Bohn, S., Sheng, C., Horbelt, D., Knaus, P., Legewie, S. and Loewer, A.
Molecular Systems Biology 14 (1): e7733. 25 January 2018

Information flow in a mammalian signal transduction pathway.
Benary, M., Nolis, I., Blüthgen, N. and Loewer, A.
In: Information- and Communication Theory in Molecular Biology. Lecture Notes in Bioengineering . Springer, Cham, Switzerland, 101-114. ISBN 978-3-319-54728-2 2018

2017

Excitability in the p53 network mediates robust signaling with tunable activation thresholds in single cells.
Mönke, G., Cristiano, E., Finzel, A., Friedrich, D., Herzel, H., Falcke, M. and Loewer, A.
Scientific Reports 7 : 46571. 18 April 2017

2016

Hyper-activation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage.
Finzel, A., Grybowski, A., Strasen, J., Cristiano, E. and Loewer, A.
Molecular Biology of the Cell 27 (15): 2360-2367. 1 August 2016

2015

Impaired myocardial development resulting in neonatal cardiac hypoplasia alters postnatal growth and stress response in the heart.
Drenckhahn, J.D., Strasen, J., Heinecke, K., Langner, P., Yin, K.V., Skole, F., Hennig, M., Spallek, B., Fischer, R., Blaschke, F., Heuser, A., Cox, T.C., Black, M.J. and Thierfelder, L.
Cardiovascular Research 106 (1): 43-54. 1 April 2015

PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors.
Schrenk-Siemens, K., Wende, H., Prato, V., Song, K., Rostock, C., Loewer, A., Utikal, J., Lewin, G.R., Lechner, S.G. and Siemens, J.
Nature Neuroscience 18 (1): 10-16. January 2015

2014

Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells.
Borcherds, W., Theillet, F.X., Katzer, A., Finzel, A., Mishall, K.M., Powell, A.T., Wu, H., Manieri, W., Dieterich, C., Selenko, P., Loewer, A. and Daughdrill, G.W.
Nature Chemical Biology 10 (12): 1000-1002. December 2014

Chlamydia infection depends on a functional MDM2-p53 axis.
Gonzalez, E., Rother, M., Kerr, M.C., Al-Zeer, M.A., Abu-Lubad, M., Kessler, M., Brinkmann, V., Loewer, A. and Meyer, T.F.
Nature Communications 5 : 5201. 13 November 2014

Differential protein occupancy profiling of the mRNA transcriptome.
Schueler, M., Munschauer, M., Gregersen, L.H., Finzel, A., Loewer, A., Chen, W., Landthaler, M. and Dieterich, C.
Genome Biology 15 (1): R15. 13 January 2014

2013

The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold.
Loewer, A., Karanam, K., Mock, C. and Lahav, G.
BMC Biology 11 (1): 114. 19 November 2013

Circular RNAs are a large class of animal RNAs with regulatory potency.
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S.D., Gregersen, L.H., Munschauer, M., Loewer, A., Ziebold, U., Landthaler, M., Kocks, C., le Noble, F. and Rajewsky, N.
Nature 495 (7441): 333-338. 21 March 2013

Dynamics of the DNA damage response: insights from live-cell imaging.
Karanam, K, Loewer, A. and Lahav, G.
Briefings in Functional Genomics 12 (2): 109-117. March 2013

2012

Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase.
Karanam, K., Kafri, R., Loewer, A. and Lahav, G.
Molecular Cell 47 (2): 320-329. 27 July 2012

p53 dynamics control cell fate.
Purvis, J.E., Karhohs, K.W., Mock, C., Batchelor, E., Loewer, A. and Lahav, G.
Science 336 (6087): 1440-1444. 15 June 2012

Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction.
Orth, J.D., Loewer, A., Lahav, G. and Mitchison, T.J.
Molecular Biology of the Cell 23 (4): 567-576. 15 February 2012

2011

We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells.
Loewer, A. and Lahav, G.
Current opinion in genetics & development 21 (6): 753-758. December 2011

Stimulus-dependent dynamics of p53 in single cells.
Batchelor, E., Loewer, A., Mock, C. and Lahav, G.
Molecular Systems Biology 7 : 488. 10 May 2011

2010

A synthetic-natural hybrid oscillator in human cells.
Toettcher, J.E., Mock, C., Batchelor, E., Loewer, A. and Lahav, G.
Proceedings of the National Academy of Sciences of the United States of America 107 (39): 17047-17052. 28 September 2010

Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells.
Loewer, A., Batchelor, E., Gaglia, G. and Lahav, G.
Cell 142 (1): 89-100. 9 July 2010

In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.
Stempfle, D., Kanwar, R., Loewer, A., Fortini, M.E. and Merdes, G.
Molecular and Cellular Biology 30 (13): 3165-3175. July 2010

2009

The ups and downs of p53: understanding protein dynamics in single cells.
Batchelor, E., Loewer, A. and Lahav, G.
Nature Reviews Cancer 9 (5): 371-377. May 2009

Distinct mechanisms act in concert to mediate cell cycle arrest.
Toettcher, J.E., Loewer, A., Ostheimer, G.J., Yaffe, M.B., Tidor, B. and Lahav, G.
Proceedings of the National Academy of Sciences of the United States of America 106 (3): 785-790. 20 January 2009

2008

Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.
Batchelor, E., Mock, C.S., Bhan, I., Loewer, A. and Lahav, G.
Molecular Cell 30 (3): 277-289. 9 May 2008

2007

Axonal accumulation of synaptic markers in APP transgenic Drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity.
Rusu, P., Jansen, A., Soba, P., Kirsch, J., Loewer, A., Merdes, G., Kuan, Y.H., Jung, A., Beyreuther, K., Kjaerulff, O. and Kins, S.
European Journal of Neuroscience 25 (4): 1079-1086. February 2007

2006

Cellular conference call: external feedback affects cell-fate decisions.
Loewer, A. and Lahav, G.
Cell 124 (6): 1128-1130. 24 March 2006

2005

Homo- and heterodimerization of APP family members promotes intercellular adhesion.
Soba, P., Eggert, S., Wagner, K., Zentgraf, H., Siehl, K., Kreger, S., Loewer, A., Langer, A., Merdes, G., Paro, R., Masters, C.L., Mueller, U., Kins, S. and Beyreuther, K.
EMBO Journal 24 (20): 3624-3634. 19 October 2005

2004

Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila.
Merdes, G., Soba, P., Loewer, A., Bilic, M.V., Beyreuther, K. and Paro, R.
EMBO Journal 23 (20): 4082-4095. 13 October 2004

Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development.
Loewer, A., Soba, P., Beyreuther, K., Paro, R. and Merdes, G.
EMBO Reports 5 (4): 405-411. April 2004