2024
The contractile machines of the heart.
Morano, I.
Advances in Experimental Medicine and Biology 1441
: 417-433.
18 June 2024
2021
Age-related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression.
Mahmoodzadeh, S., Koch, K., Schriever, C., Xu, J., Steinecker, M., Leber, J., Dworatzek, E., Purfürst, B., Kunz, S., Recchia, D., Canepari, M., Heuser, A., Di Francescantonio, S. and Morano, I.
Journal of Cachexia Sarcopenia and Muscle 12
: 1249-1265.
14 October 2021
2020
Selective androgen receptor modulators (SARMs) as pharmacological treatment for muscle wasting in ongoing clinical trials.
Peixoto da Fonseca, G.W., Dworatzek, E., Ebner, N. and von Haehling, S.
Expert Opinion on Investigational Drugs 29
(8): 881-891.
August 2020
2019
The role of 17β-estradiol and estrogen receptors in regulation of Ca(2+) channels and mitochondrial function in cardiomyocytes.
Mahmoodzadeh, S. and Dworatzek, E.
Frontiers in Endocrinology 10
: 310.
May 2019
Sex-specific regulation of collagen I and III expression by 17β-estradiol in cardiac fibroblasts: role of estrogen receptors.
Dworatzek, E., Mahmoodzadeh, S., Schriever, C., Kusumoto, K., Kramer, L., Santos, G., Fliegner, D., Leung, Y.K., Ho, S.M., Zimmermann, W.H., Lutz, S. and Regitz-Zagrosek, V.
Cardiovascular Research 115
(2): 315-327.
1 February 2019
2017
Protein kinase A regulates C-terminally truncated Ca(V) 1.2 in Xenopus oocytes: roles of N- and C-termini of the α(1C) subunit.
Oz, S., Pankonien, I., Belkacemi, A., Flockerzi, V., Klussmann, E., Haase, H. and Dascal, N.
Journal of Physiology 595
(10): 3181-3202.
15 May 2017
Protective function of Ahnak1 in vascular healing after wire injury.
Haase, N., Rüder, C., Haase, H., Kamann, S., Kouno, M., Morano, I., Dechend, R., Zohlnhöfer, D. and Haase, T.
Journal of Vascular Research 54
(3): 131-142.
May 2017
Targeted basic research to highlight the role of estrogen and estrogen receptors in the cardiovascular system.
Dworatzek, E. and Mahmoodzadeh, S.
Pharmacological Research 119
: 27-35.
May 2017
17β-estradiol-induced interaction of estrogen receptor α and human atrial essential myosin light chain modulates cardiac contractile function.
Duft, K., Schanz, M., Pham, H., Abdelwahab, A., Schriever, C., Kararigas, G., Dworatzek, E., Davidson, M.M., Regitz-Zagrosek, V., Morano, I. and Mahmoodzadeh, S.
Basic Research in Cardiology 112
(1): 1.
January 2017
2016
Essential myosin light chains regulate myosin function and muscle contraction.
Morano, I.
In:
Muscle Contraction and Cell Motility.
Pan Stanford Publishing, Singapore, 273-288.
ISBN 9789814745161
1 November 2016
Nuclear translocation of the cardiac L-type calcium channel C-terminus is regulated by sex and 17β-estradiol.
Mahmoodzadeh, S., Haase, H., Sporbert, A., Rharass, T., Panáková, D. and Morano, I.
Journal of Molecular and Cellular Cardiology 97
: 226-234.
August 2016
Muscle RING-finger 2 and 3 maintain striated-muscle structure and function.
Lodka, D., Pahuja, A., Geers-Knörr, C., Scheibe, R., Nowak, M., Hamati, J., Köhncke, C., Purfürst, B., Kanashova, T., Schmidt, S., Glass, D.J., Morano, I., Heuser, A., Kraft, T., Bassel-Duby, R., Olson, E.N., Dittmar, G., Sommer, T. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 7
(2): 165-180.
May 2016
4D visualization of replication foci in mammalian cells corresponding to individual replicons.
Chagin, V.O., Casas-Delucchi, C.S., Reinhart, M., Schermelleh, L., Markaki, Y., Maiser, A., Bolius, J.J., Bensimon, A., Fillies, M., Domaing, P., Rozanov, Y.M., Leonhardt, H. and Cardoso, M.C.
Nature Communications 7
: 11231.
7 April 2016
Cardiomyocyte-specific overexpression of estrogen receptor beta improves survival and cardiac function after myocardial infarction in female and male mice.
Schuster, I., Mahmoodzadeh, S., Dworatzek, E., Jaisser, F., Messaoudi, S., Morano, I. and Regitz-Zagrosek, V.
Clinical Science 130
(5): 365-376.
26 January 2016
The contractile apparatus of the heart.
Morano, I.
In:
Congenital Heart Diseases: The Broken Heart : Clinical Features, Human Genetics and Molecular Pathways.
Springer, Vienna, 237-250.
ISBN 978-3-7091-1882-5
2016
2015
Interaction of epoxyeicosatrienoic acids and adipocyte fatty acid-binding protein in the modulation of cardiomyocyte contractility.
Lamounier-Zepter, V., Look, C., Schunck, W.H., Schlottmann, I., Woischwill, C., Bornstein, S.R., Xu, A. and Morano, I.
International Journal of Obesity 39
(5): 755-761.
May 2015
Susceptibility of murine induced pluripotent stem cell-derived cardiomyocytes to hypoxia and nutrient deprivation.
Brodarac, A., Šarić, T., Oberwallner, B., Mahmoodzadeh, S., Neef, K., Albrecht, J., Burkert, K., Oliverio, M., Nguemo, F., Choi, Y.H., Neiss, W.F., Morano, I., Hescheler, J. and Stamm, C.
Stem Cell Research & Therapy 6
(1): 83.
23 April 2015
17β-estradiol regulates mTORC2 sensitivity to rapamycin in adaptive cardiac remodeling.
Kusch, A., Schmidt, M., Gürgen, D., Postpieszala, D., Catar, R., Hegner, B., Davidson, M.M., Mahmoodzadeh, S. and Dragun, D.
PLoS ONE 10
(4): e0123385.
16 April 2015
2014
Molecular mechanism regulating myosin and cardiac functions by ELC.
Lossie, J., Köhncke, C., Mahmoodzadeh, S., Steffen, W., Canepari, M., Maffei, M., Taube, M., Larchevêque, O., Baumert, P., Haase, H., Bottinelli, R., Regitz-Zagrosek, V. and Morano, I.
Biochemical and Biophysical Research Communications 450
(1): 464-469.
18 July 2014
Distinct interactions between actin and essential myosin light chain isoforms.
Petzhold, D., Simsek, B., Meißner, R., Mahmoodzadeh, S. and Morano, I.
Biochemical and Biophysical Research Communications 449
(3): 284-288.
4 July 2014
Attenuated response of ICa,L to nitric oxide in atrial fibrillation.
Rozmaritsa, N., Christ, T., Van Wagoner, D.R., Haase, H., Stasch, J.P., Matschke, K. and Ravens, U.
Cardiovascular Research 101
(3): 533-542.
1 March 2014
Cardiomyocyte-specific estrogen receptor alpha increases angiogenesis, lymphangiogenesis and reduces fibrosis in the female mouse heart post-myocardial infarction.
Mahmoodzadeh, S., Leber, J., Zhang, X., Jaisser, F., Messaoudi, S., Morano, I., Furth, P.A., Dworatzek, E. and Regitz-Zagrosek, V.
Journal of Cell Science & Therapy 5
(1): 153.
30 January 2014
2013
Amyloid-β peptides activate α1-adrenergic cardiovascular receptors.
Haase, N., Herse, F., Spallek, B., Haase, H., Morano, I., Qadri, F., Szijártó, I.A., Rohm, I., Yilmaz, A., Warrington, J.P., Ryan, M.J., Gollasch, M., Müller, D.N., Dechend, R. and Wallukat, G.
Hypertension 62
(5): 966-972.
November 2013
Proteomic investigation of the interactome of FMNL1 in hematopoietic cells unveils a role in calcium-dependent membrane plasticity.
Han, Y., Yu, G., Sarioglu, H., Caballero-Martinez, A., Schlott, F., Ueffing, M., Haase, H., Peschel, C. and Krackhardt, A.M.
Journal of Proteomics 78
: 72-82.
14 January 2013
2012
Modulation of distinct isoforms of L-type calcium channels by Gq-coupled receptors in Xenopus oocytes: Antagonistic effects of Gβγ and protein kinase C.
Weiss, S., Keren-Raifman, T., Oz, S., Ben Mocha, A., Haase, H. and Dascal, N.
Channels 6
(6): 426-437.
1 November 2012
Ahnak1 interaction is affected by phosphorylation of Ser-296 on Cavβ(2).
Pankonien, I., Otto, A., Dascal, N., Morano, I. and Haase, H.
Biochemical and Biophysical Research Communications 421
(2): 184-189.
4 May 2012
Mutations of ventricular essential myosin light chain disturb myosin binding and sarcomeric sorting.
Lossie, J., Ushakov, D.S., Ferenczi, M.A., Werner, S., Keller, S., Haase, H. and Morano, I.
Cardiovascular Research 93
(3): 390-396.
1 March 2012
The hinge region of the scaffolding protein of cell contacts, zonula occludens protein 1, regulates interacting with various signaling proteins.
Bal, M.S., Castro, V., Piontek, J., Rueckert, C., Walter, J.K., Shymanets, A., Kurig, B., Haase, H., Nuernberg, B. and Blasig, I.E.
Journal of Cellular Biochemistry 113
(3): 934-945.
March 2012
PI3kγ inhibition reduces blood pressure by a vasorelaxant Akt/LTCC mechanism.
Carnevale, D., Vecchione, C., Mascio, G., Esposito, G., Cifelli, G., Martinello, K., Landolfi, A., Selvetella, G., Grieco, P., Damato, A., Franco, E., Haase, H., Maffei, A., Ciraolo, E., Fucile, S., Frati, G., Mazzoni, O., Hirsch, E. and Lembo, G.
Cardiovascular Research 93
(1): 200-209.
1 January 2012
Impaired modulation of the cardiac L-type Ca2+ channel activity by ahnak-1 after myocardial infarction.
Alvarez Gonzalez, J., Haase, H., Vassort, G. and Morano, I.
Revista Cubana de Cardiologia y Cirugia Cardiovascular 18
(3): 142-148.
2012
2011
Ahnak1 abnormally localizes in muscular dystrophies and contributes to muscle vesicle release.
Zacharias, U., Purfürst, B., Schoewel, V., Morano, I., Spuler, S. and Haase, H.
Journal of Muscle Research and Cell Motility 32
(4-5): 271-280.
December 2011
Ahnak1 is a tuneable modulator of cardiac Ca(v)1.2 calcium channel activity.
Pankonien, I., Alvarez, J.L., Doller, A., Koehncke, C., Rotte, D., Regitz-Zagrosek, V., Morano, I. and Haase, H.
Journal of Muscle Research and Cell Motility 32
(4-5): 281-290.
December 2011
Spinophilin is required for normal morphology, Ca(2+) homeostasis and contraction but dispensable for beta-adrenergic stimulation of adult cardiomyocytes.
Petzhold, D., da Costa-Goncalves, A.C., Gross, V. and Morano, I.
Journal of Muscle Research and Cell Motility 32
(4-5): 243-248.
December 2011
BMS309403 directly suppresses cardiac contractile function.
Look, C., Morano, I., Ehrhart-Bornstein, M., Bornstein, S.R. and Lamounier-Zepter, V.
Naunyn-Schmiedeberg's Archives of Pharmacology 384
(3): 255-263.
September 2011
Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides.
Lättig-Tünnemann, G., Prinz, M., Hoffmann, D., Behlke, J., Palm-Apergi, C., Morano, I., Herce, H.D. and Cardoso, M.C.
Nature Communications 2
: 453.
30 August 2011
Photocontrol of contracting muscle fibers.
Hoppmann, C., Schmieder, P., Domaing, P., Vogelreiter, G., Eichhorst, J., Wiesner, B., Morano, I., Rueck-Braun, K. and Beyermann, M.
Angewandte Chemie International Edition 50
(33): 7699-7702.
8 August 2011
Angiotensin II type 1 receptor antibodies and increased angiotensin II sensitivity in pregnant rats.
Wenzel, K., Rajakumar, A., Haase, H., Geusens, N., Hubner, N., Schulz, H., Brewer, J., Roberts, L., Hubel, C.A., Herse, F., Hering, L., Qadri, F., Lindschau, C., Wallukat, G., Pijnenborg, R., Heidecke, H., Riemekasten, G., Luft, F.C., Muller, D.N., Lamarca, B. and Dechend, R.
Hypertension 58
(1): 77-84.
July 2011
Human essential myosin light chain isoforms revealed distinct myosin binding, sarcomeric sorting, and inotropic activity.
Petzhold, D., Lossie, J., Keller, S., Werner, S., Haase, H. and Morano, I.
Cardiovascular Research 90
(3): 513-520.
1 June 2011
Small molecule AKAP/PKA interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes.
Christian, F., Szaszak, M., Friedl, S., Drewianka, S., Lorenz, D., Goncalves, A., Furkert, J., Vargas, C., Schmieder, P., Goetz, F., Zuehlke, K., Moutty, M., Goettert, H., Joshi, M., Reif, B., Haase, H., Morano, I., Grossmann, S., Klukovits, A., Verli, J., Gaspar, R., Noack, C., Bergmann, M., Kass, R., Hampel, K., Kashin, D., Genieser, H.G., Herberg, F.W., Willoughby, D., Cooper, D.M., Baillie, G.S., Houslay, M.D., von Kries, J.P., Zimmermann, B., Rosenthal, W. and Klussmann, E.
Journal of Biological Chemistry 286
(11): 9079-9096.
18 March 2011
A myomesin mutation associated with hypertrophic cardiomyopathy deteriorates dimerisation properties.
Siegert, R., Perrot, A., Keller, S., Behlke, J., Michalewska-Wludarczyk, A., Wycisk, A., Tendera, M., Morano, I. and Oezcelik, C.
Biochemical and Biophysical Research Communications 405
(3): 473-479.
18 February 2011
Adipocyte-derived factors suppress heart contraction.
Look, C., Morano, I., Ehrhart-Bornstein, M., Bornstein, S.R. and Lamounier-Zepter, V.
International Journal of Obesity 35
(1): 84-90.
January 2011
2010
AHNAK1 and AHNAK2 are costameric proteins: AHNAK1 affects transverse skeletal muscle fiber stiffness.
Marg, A., Haase, H., Neumann, T., Kouno, M. and Morano, I.
Biochemical and Biophysical Research Communications 401
(1): 143-148.
8 October 2010
Ahnak1 modulates L-type Ca(2+) channel inactivation of rodent cardiomyocytes.
Alvarez, J.L., Petzhold, D., Pankonien, I., Behlke, J., Kouno, M., Vassort, G., Morano, I. and Haase, H.
Pfluegers Archiv European Journal of Physiology 460
(4): 719-730.
September 2010
Auto-inhibitory effects of an IQ motif on protein structure and function.
Petzhold, D., Lossie, J., Behlke, J., Keller, S., Haase, H. and Morano, I.
Biochemical and Biophysical Research Communications 396
(4): 939-943.
11 June 2010
Agonistic antibody to the alpha(1)-adrenergic receptor mobilizes intracellular calcium and induces phosphorylation of a cardiac 15-kDa protein.
Karczewski, P., Haase, H., Hempel, P. and Bimmler, M.
Molecular and Cellular Biochemistry 333
(1-2): 233-242.
January 2010
2009
Connective tissue growth factor overexpression in cardiomyocytes promotes cardiac hypertrophy and protection against pressure overload.
Panek, A.N., Posch, M.G., Alenina, N., Ghadge, S.K., Erdmann, B., Popova, E., Perrot, A., Geier, C., Dietz, R., Morano, I., Bader, M. and Oezcelik, C.
PLoS ONE 4
(8): e6743.
25 August 2009
Adipocyte fatty acid-binding protein suppresses cardiomyocyte contraction. A new link between obesity and heart disease.
Lamounier-Zepter, V., Look, C., Alvarez, J., Christ, T., Ravens, U., Schunck, W.H., Ehrhart-Bornstein, M., Bornstein, S.R. and Morano, I.
Circulation Research 105
(4): 326-334.
14 August 2009
Cell-penetrating HIV1 TAT peptides float on model lipid bilayers.
Ciobanasu, C., Harms, E., Tünnemann, G., Cardoso, M.C. and Kubitscheck, U.
Biochemistry 48
(22): 4728-4737.
9 June 2009
Hypoxia induces dilated cardiomyopathy in the chick embryo: mechanism, intervention, and long-term consequences.
Tintu, A., Rouwet, E., Verlohren, S., Brinkmann, J., Ahmad, S., Crispi, F., van Bilsen, M., Carmeliet, P., Staff, A.C., Tjwa, M., Cetin, I., Gratacos, E., Hernandez-Andrade, E., Hofstra, L., Jacobs, M., Lamers, W.H., Morano, I., Safak, E., Ahmed, A. and le Noble, F.
PLoS ONE 4
(4): e5155.
9 April 2009
2008
Human adipocyte-derived factors directly inhibit cardiac contraction.
Look, C., Morano, I. and Lamounier-Zepter, V.
Journal of Muscle Research and Cell Motility 29
(6-8): 181-184.
December 2008
Microinjected antibodies interfere with protein nucleocytoplasmic shuttling by distinct molecular mechanisms.
Marg, A., Meyer, T., Vigneron, M. and Vinkemeier, U.
Cytometry Part A 73A
(12): 1128-1140.
December 2008
Potential relevance of alpha(1)-adrenergic receptor autoantibodies in refractory hypertension.
Wenzel, K., Haase, H., Wallukat, G., Derer, W., Bartel, S., Homuth, V., Herse, F., Huebner, N., Schulz, H., Janczikowski, M., Lindschau, C., Schroeder, C., Verlohren, S., Morano, I., Mueller, D.N., Luft, F.C., Dietz, R., Dechend, R. and Karczewski, P.
PLoS ONE 3
(11): e3742.
17 November 2008
Analysis of CD97 expression and manipulation: Antibody treatment but not gene targeting curtails granulocyte migration.
Veninga, H., Becker, S., Hoek, R.M., Wobus, M., Wandel, E., van der Kaa, J., van der Valk, M., de Vos, A.F., Haase, H., Owens, B., van der Poll, T., van Lier, R.A., Verbeek, J.S., Aust, G. and Hamann, J.
Journal of Immunology 181
(9): 6574-6583.
1 November 2008
2007
Modulation of muscle contraction by a cell-permeable peptide.
Tünnemann, G., Karczewski, P., Haase, H., Cardoso, M.C. and Morano, I.
Journal of Molecular Medicine 85
(12): 1405-1412.
December 2007
Atrial glutathione content, calcium current, and contractility.
Carnes, C.A., Janssen, P.M.L., Ruehr, M.L., Nakayama, H., Nakayama, T., Haase, H., Bauer, J.A., Chung, M.K., Fearon, I.M., Gillinov, A.M., Hamlin, R.L. and van Wagoner, D.R.
Journal of Biological Chemistry 282
(38): 28063-28073.
21 September 2007
Molecular modeling of the myosin-S1(A1) isoform.
Aydt, E.M., Wolff, G. and Morano, I.
Journal of Structural Biology 159
(1): 158-163.
July 2007
Impact of testosterone on cardiac L-type calcium channels and Ca(2+) sparks: Acute actions antagonize chronic effects.
Er, F., Michels, G., Brandt, M.C., Khan, I., Haase, H., Eicks, M., Lindner, M. and Hoppe, U.C.
Cell Calcium 41
(5): 467-477.
1 May 2007
Ahnak, a new player in beta-adrenergic regulation of the cardiac L-type Ca(2+) channel.
Haase, H.
Cardiovascular Research 73
(1): 19-25.
1 January 2007
Patients with a non-dysferlin Miyoshi myopathy have a novel membrane repair defect.
Jaiswal, J.K., Marlow, G., Summerill, G., Mahjneh, I., Mueller, S., Hill, M., Miyake, K., Haase, H., Anderson, L.V., Richard, I., Kiuru-Enari, S., McNeil, P.L., Simon, S.M. and Bashir, R.
Traffic 8
(1): 77-88.
January 2007
Intracellular calcium in hypertrophic smooth muscle from rat urinary bladder.
Arner, A., Scott, R.S., Haase, H., Morano, I. and Uvelius, B.
Scandinavian Journal of Urology and Nephrology 41
(4): 270-277.
2007
2006
Human adipocytes attenuate cardiomyocyte contraction: characterization of an adipocyte-derived negative inotropic activity.
Lamounier-Zepter, V., Ehrhart-Bornstein, M., Karczewski, P., Haase, H., Bornstein, S.R. and Morano, I.
FASEB Journal 20
(10): 1653-1659.
August 2006
Minigenes encoding N-terminal domains of human cardiac myosin light chain-1 improve heart function of transgenic rats.
Haase, H., Dobbernack, G., Tünnemann, G., Karczewski, P., Cardoso, C., Petzhold, D., Schlegel, W.P., Lutter, S., Pierschalek, P., Behlke, J. and Morano, I.
FASEB Journal 20
(7): 865-873.
May 2006
Heart.
Morano, I.
In:
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 1.
Springer, Berlin [u.a.], 743-748.
ISBN 3-540-44244-8
2006
Muscle contraction.
Morano, I.
In:
Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine ; Vol. 2.
Springer, Berlin [u.a.], 1215-1219.
ISBN 3-540-44244-8
2006
2005
Constriction velocities of renal afferent and efferent arterioles of mice are not related to SMB expression.
Patzak, A., Petzhold, D., Wronski, T., Martinka, P., Babu, G.J., Periasamy, M., Haase, H. and Morano, I.
Kidney International 68
(6): 2726-2734.
1 December 2005
Ahnak is critical for cardiac Ca(v)1.2 calcium channel function and its beta-adrenergic regulation.
Haase, H., Alvarez, J., Petzhold, D., Doller, A., Behlke, J., Erdmann, J., Hetzer, R., Regitz-Zagrosek, V., Vassort, G. and Morano, I.
FASEB Journal 19
(14): 1969-1977.
December 2005
Human atrial myosin light chain 1 expression attenuates heart failure.
Abdelaziz, A.I., Pagel, I., Schlegel, W.P., Kott, M., Monti, J., Haase, H. and Morano, I.
Advances in Experimental Medicine and Biology 565
: 283-292.
1 January 2005
Reconstitution of ventricular myosin with atrial light chains-1 improves its functional properties.
Khalina, Y.N., Bartsch, H., Petzhold, D., Haase, H., Podlubnaya, Z.A., Shpagina, M.D. and Morano, I.
Acta Biochimica Polonica 52
(2): 443-448.
1 January 2005
Regulation of naturally occurring antisense RNA of myosin heavy chain (MyHC) in neonatal cardiomyocytes.
Luther, H.P., Bartsch, H., Morano, I., Podlowski, S. and Baumann, G.
Journal of Cellular Biochemistry 94
: 848-855.
1 January 2005
Regulation of the human atrial myosin light chain 1 promoter by Ca2+-calmodulin-dependent signaling pathways.
Woischwill, C., Karczewski, P., Bartsch, H., Luther, H.P., Kott, M., Haase, H. and Morano, I.
FASEB Journal 19
(6): 503-511.
1 January 2005
Regulation of smooth muscle contraction.
Morano, I.
In:
Interventions for Persisting Ductus Arteriosus in the Preterm Infant.
Springer, Berlin, Germany, 6-11.
ISBN 978-3-540-24511-7
2005
2004
Untersuchungen zur Funktion der humanen atrialen essentiellen leichten Myosinkette (ALC-1) in einem transgenen Rattenmodell.
Abdelaziz, A.I.
UNSPECIFIED thesis, UNSPECIFIED.
30 September 2004
α-tropomyosin mutations Asp175Asn and Glu180Gly affect cardiac function in transgenic rats in different ways.
Wernicke, D., Thiel, C., Duja-Isac, C.M., Essine, K.V., Spindler, M., Nunez, D.J.R., Plehm, R., Wessel, N., Hammes, A., Edwards, R.J., Lippoldt, A., Zacharias, U., Stroemer, H., Neubauer, S., Davies, M.J., Morano, I. and Thierfelder, L.
American Journal of Physiology Regulatory Integrative and Comparative Physiology 287
(3): R685-R695.
1 September 2004
The carboxyl-terminal ahnak domain induces actin bundling and stabilizes muscle contraction.
Haase, H., Pagel, I., Khalina, Y., Zacharzowsky, U., Person, V., Lutsch, G., Petzhold, D., Kott, M., Schaper, J. and Morano, I.
FASEB Journal 18
(7): 839-841.
May 2004
Calcium current in rat cardiomyocytes is modulated by the carboxyl-terminal ahnak domain.
Alvarez, J., Hamplova, J., Hohaus, A., Morano, I., Haase, H. and Vassort, G.
Journal of Biological Chemistry 279
(13): 12456-12461.
26 March 2004
Detection of a novel sense-antisense RNA-hybrid structure by RACE experiments on endogenous troponin I antisense RNA.
Bartsch, H., Voigtsberger, S., Baumann, G., Morano, I. and Luther, H.P.
RNA 10
(8): 1215-1224.
1 January 2004
Functional characterization of the human atrial essential myosin light chain (hALC-1) in a transgenic rat model.
Abdelaziz, A.I., Segaric, J., Bartsch, H., Petzhold, D., Schlegel, W., Kott, M., Seefeldt, I., Klose, J., Bader, M., Haase, H. and Morano, I.
Journal of Molecular Medicine 82
(4): 265-274.
1 January 2004
Mouse Ahnak (desmoyokin) homologous to human AHNAK [Accession: AY369977 / Locus: AY367634S2 / Organism: Mus musculus (house mouse)].
Petzhold, D., Bader, M., Bartsch, H., Hohaus, A., Morano, I. and Haase, H.
Nucleotide (GenBank)
1 January 2004
Regional expression of L-type calcium channel subunits during cardiac development.
Acosta, L., Haase, H., Morano, I., Moorman, A.F.M. and Franco, D.
Developmental Dynamics 230
(1): 131-136.
1 January 2004
2003
Tuning smooth muscle contraction by molecular motors.
Morano, I.
Journal of Molecular Medicine 81
(8): 481-487.
August 2003
Androgen receptor independent cardiovascular action of the antiandrogen flutamide.
Iliescu, R., Campos, L.A., Schlegel, W.P., Morano, I., Baltatu, O. and Bader, M.
Journal of Molecular Medicine 81
(7): 420-427.
July 2003
The L-type Ca2+ channel subunits alpha1c and beta2 are not downregulated in atrial myocardium of patients with chronic atrial fibrillation.
Schotten, U., Haase, H., Frechen, D., Greiser, M., Stellbrink, C., Vazguez-Jimenez, J.F., Morano, I., Allessie, M.A. and Hanrath, P.
Journal of Molecular and Cellular Cardiology 35
(5): 437-443.
May 2003
Smooth, slow and smart muscle motors.
Arner, A., Loefgren, M. and Morano, I.
Journal of Muscle Research and Cell Motility 24
(2): 165-173.
April 2003
Nonmuscle myosin motor of smooth muscle.
Loefgren, M., Ekblad, E., Morano, I. and Arner, A.
Journal of General Physiology 121
(4): 301-310.
31 March 2003
Molecular mechanisms of early electrical remodeling: transcriptional downregulation of ion channel subunits reduces I(Ca,L) and I(to) in rapid atrial pacing in rabbits.
Bosch, R.F., Scherer, C.R., Rueb, N., Woehrl, S., Steinmeyer, K., Haase, H., Busch, A.E., Seipel, L. and Kuehlkamp, V.
Journal of the American College of Cardiology 41
(5): 858-869.
5 March 2003
Expression of smooth muscle MyHC B in blood vessels of hypertrophied heart in experimentally hypertensive rats.
Wetzel, K., Baltatu, O., Nafz, B., Persson, P.B., Haase, H. and Morano, I.
American Journal of Physiology Regulatory Integrative and Comparative Physiology 284
(2): R607-R610.
1 February 2003
Analyse der Funktion der nichtmuskulaeren schweren Myosinketten in glatten Muskelzellen.
Lamounier-Zepter, V.
UNSPECIFIED thesis, UNSPECIFIED.
13 January 2003
Protein-Fragmente, die vom C-Terminus des AHNAK-Proteins abgeleitet sind, sowie ihre Verwendung zur Kraftsteigerung im Skelettmuskel.
Morano, I.
DE10160158A1.
2 January 2003
Distinct contractile systems for electromechanical and pharmacomechanical coupling in smooth muscle.
Lamounier-Zepter, V., Baltas, L.G. and Morano, I.
Advances in Experimental Medicine and Biology 538
: 417-425.
1 January 2003
2002
BALF N-acetylglucosaminidase and β-galactosidase activities in idiopathic pulmonary fibrosis.
Gessner, C., Wirtz, H., Sack, U., Winkler, J., Stiehl, P., Schauer, J. and Wolff, G.
Respiratory Medicine 96
(9): 751-756.
September 2002
The C-terminal region of ahnak provides a link between cardiac L-type Ca2+ calcium channels and the actin-based cytoskeleton.
Hohaus, A., Person, V., Behlke, J., Schaper, J., Morano, I. and Haase, H.
FASEB Journal 16
(10): 1205-1216.
August 2002
Analysis of the energetic state of heart cells after adenovirus-mediated expression of hALC-1.
Zacharzowsky, U.B., Wolff, G., Kott, M., Haase, H., Bartsch, H., Nuessler, A.K., Baltas, L.G., Karawajew, L. and Morano, I.
Journal of Cellular Biochemistry 86
(3): 422-431.
20 June 2002
Anwendung herzspezifischer Transkriptionsfaktoren vom basischen Helix-Loop-Helix-Typ zur Behandlung der Herzinsuffizienz [Use of heart-specific transcription factors of the basic helix-loop-helix type for treating cardiac power failure].
Morano, I.
DE10154224A1 ; WO0238781.
20 June 2002
Mice with cardiac-specific sequestration of the β-subunit of the L-type calcium channel.
Serikov, V., Bodi, I., Koch, S.E., Muth, J.N., Mikala, G., Martinov, S.G., Haase, H. and Schwartz, A.
Biochemical and Biophysical Research Communications 293
(5): 1405-1411.
24 May 2002
BAX and p16INK4A are independent positive prognostic markers for advance tumour stage of nonsmall cell lung cancer.
Gessner, C., Liebers, U., Kuhn, H., Stiehl, P., Witt, C., Schauer, J. and Wolff, G.
European Respiratory Journal 19
: 134-140.
1 January 2002
Cardiac troponin I sense-antisense RNA duplexes in the myocardium.
Podlowski, S., Bramlage, P., Baumann, G., Morano, I. and Luther, H.P.
Journal of Cellular Biochemistry 85
(1): 198-207.
1 January 2002
Nitric oxide synthase upregulation and the predelivery blood pressure decrease in spontaneously hypertensive rats.
Gompf, H., Luft, F.C. and Morano, I.
Journal of Hypertension 20
: 255-261.
1 January 2002
2001
Mittel zur Behandlung von Herzerkrankungen.
Morano, I.
DE10035098A1 ; WO0105419.
17 May 2001
Increased expression of non-muscle myosin heavy chain-B in connective tissue cells of hypertrophic rat urinary bladder.
Sjuve, R., Haase, H., Ekblad, E., Malmqvist, U., Morano, I. and Arner, A.
Cell and Tissue Research 304
(2): 271-278.
1 January 2001
2000
Diagnostischer Marker fuer das Humanherz.
Morano, I. and Haase, H.
DE19919205A1 ; EP1171461.
2 November 2000
Modulation of the smooth-muscle L-type Ca2+ channel alpha1 subunit (alpha1C-b) by the beta2a subunit: a peptide which inhibits binding of beta to the I-II linker of alpha1 induces functional uncoupling.
Hohaus, A., Poteser, M., Romanin, C., Klugbauer, N., Hofmann, F., Morano, I., Haase, H. and Groschner, K.
Biochemical Journal 348
(3): 657-665.
15 June 2000
Smooth-muscle contraction without smooth-muscle myosin.
Morano, I., Chai, G.X., Baltas, L.G., Lamounier-Zepter, V., Lutsch, G., Kott, M., Haase, H. and Bader, M.
Nature Cell Biology 2
(6): 371-375.
1 June 2000
beta Subunit heterogeneity of L-type Ca2+ channels in smooth muscle tissues.
Reimer, D., Huber, I.G., Garcia, M.L., Haase, H. and Striessnig, J.
FEBS Letters 467
(1): 65-69.
4 February 2000
Expression of Ca2+ channel subunits during cardiac ontogeny in mice and rats: Identification of fetal alpha1C and beta subunit isoforms.
Haase, H., Pfitzmaier, B., McEnery, M.W. and Morano, I.
Journal of Cellular Biochemistry 76
(4): 695-703.
1 January 2000
Modulation of cardiac function by essential myosin light chains in health and disease.
Morano, I.
In:
Molecular Approaches to Heart Failure Therapy.
Steinkopff, Berlin, 285-297.
ISBN 3-7985-1236-1
1 January 2000
The human beta-myosin heavy chain gene: Sequence diversity and functional characteristics of the protein.
Wendel, B., Reinhard, R., Wachtendorf, U., Zacharzowsky, U.B., Osterziel, K.J., Schulte, H.D., Haase, H., Hoehe, M.R. and Morano, I.
Journal of Cellular Biochemistry 79
(4): 566-575.
1 January 2000
1999
Signaling from beta-adrenoceptor to L-type calcium channel: identification of a novel cardiac protein kinase A target possessing similarities to AHNAK.
Haase, H., Podzuweit, T., Lutsch, G., Hohaus, A., Kostka, S., Lindschau, C., Kott, M., Kraft, R. and Morano, I.
FASEB Journal 13
(15): 2161-2172.
December 1999
Remodeling of the hypertrophied human myocardium by cardiac bHLH transcription factors.
Ritter, O., Haase, H., Schulte, H.D., Lange, P.E. and Morano, I.
Journal of Cellular Biochemistry 74
: 551-561.
15 September 1999
Expression of atrial myosin light chains but not alpha-myosin heavy chains is correlated in vivo with increased ventricular function in patients with hypertrophic obstructive cardiomyopathy.
Ritter, O., Luther, H.P., Haase, H., Baltas, L.G., Baumann, G., Schulte, H.D. and Morano, I.
Journal of Molecular Medicine 77
(9): 677-685.
September 1999
Inhibition of crossbridge function in the normal human heart by hypoxic endothelial superfusate.
Zacharzowsky, U.B., Shah, A.M., Haase, H. and Morano, I.
Biochemical and Biophysical Research Communications 262
: 64-67.
19 August 1999
Tuning the human heart molecular motors by myosin light chains.
Morano, I.
Journal of Molecular Medicine 77
: 544-555.
1 July 1999
Regulation of Limulus skeletal muscle contraction.
Ritter, O., Haase, H. and Morano, I.
FEBS Letters 446
: 233-235.
12 March 1999
Plakoglobin is essential for myocardial compliance but dispensable for myofibril insertion into adherens junctions.
Isac, C.M., Ruiz, P., Pfitzmaier, B., Haase, H., Birchmeier, W. and Morano, I.
Journal of Cellular Biochemistry 72
(1): 8-15.
1 January 1999
1998
Mittel zur Steigerung der Herzkraft [Agent for enhancing the heart force].
Morano, I.
DE19720162A1 ; EP0979094 ; WO9850057A2 ; WO9850057A3.
5 November 1998
Expression of smooth muscle myosin heavy chain B in cardiac vessels of normotensive and hypertensive rats.
Wetzel, U., Lutsch, G., Haase, H., Ganten, U. and Morano, I.
Circulation Research 83
(2): 204-209.
27 July 1998
A new efficient method for transfection of neonatal cardiomyocytes using histone H1 in combination with DOSPER liposomal transfection reagent.
Kott, M., Haberland, A., Zaitsev, S., Buchberger, B., Morano, I. and Boettger, M.
Somatic Cell and Molecular Genetics 24
(4): 257-261.
July 1998
Differential expression and association of calcium channel alpha1B and beta subunits during rat brain ontogeny.
Vance, C.L., Begg, C.M., Lee, W.L., Haase, H., Copeland, T.D. and McEnery, M.W.
Journal of Biological Chemistry 273
(23): 14495-14502.
5 June 1998
Modulation of contractility in human cardiac hypertrophy by myosin essential light chain isoforms.
Schaub, M.C., Hefti, M.A., Zuellig, R.A. and Morano, I.
Cardiovascular Research 37
(2): 381-404.
February 1998
Characterization of naturally occurring myosin heavy chain antisense mRNA in rat heart.
Luther, H.P., Haase, H., Hohaus, A., Beckmann, G., Reich, J. and Morano, I.
Journal of Cellular Biochemistry 70
: 110-120.
1 January 1998
Immunocytochemical localization of the G-protein sub-unit, Goalpha in rat heart. Implications for a role of Goalpha in secretion of cardiac hormones.
Wolf, W.P., Spicher, K., Haase, H. and Schulze, W.
Journal of Molecular and Cellular Cardiology 30
: 1149-1162.
1 January 1998
L-type calcium channel expression depends on the differentiated state of vascular smooth muscle cells.
Gollasch, M., Haase, H., Ried, C., Lindschau, C., Morano, I., Luft, F.C. and Haller, H.
FASEB Journal 12
: 593-601.
1 January 1998
Phosphorylation of phospholamban correlates with relaxation of coronary artery induced by nitric oxide, adenosine, and prostacyclin in the pig.
Karczewski, P., Hendrischke, T., Wolf, W.P., Morano, I., Bartel, S. and Schrader, J.
Journal of Cellular Biochemistry 70
: 49-59.
1 January 1998
Expression and function of atrial myosin light chain 1 in the porcine right ventricle of normal and pulmonary hypertensive animals.
Morano, M., Boels, P., Haworth, S.G., Haase, H. and Morano, I.
Advances in Experimental Medicine and Biology 453
: 481-489.
1998
1997
From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: a retinoic acid and db-cAMP in vitro differentiation model.
Drab, M., Haller, H., Bychkov, R., Erdmann, B., Lindschau, C., Haase, H., Morano, I., Luft, F.C. and Wobus, A.M.
FASEB Journal 11
(11): 905-915.
September 1997
Beta subunit heterogeneity in neuronal L-type Ca2+ channels.
Pichler, M., Cassidy, T.N., Reimer, D., Haase, H., Krause, R., Ostler, D. and Striessnig, J.
Journal of Biological Chemistry 272
(21): 13877-13882.
23 May 1997
Changes in essential myosin light chain isoform expression provide a molecular basis for isometric force regulation in the failing human heart.
Morano, I., Haedicke, K., Haase, H., Boehm, M., Erdmann, E. and Schaub, M.C.
Journal of Molecular and Cellular Cardiology 29
(4): 1177-1187.
April 1997
Alternative splicing and cycling kinetics of myosin change during hypertrophy of human smooth muscle cells.
Morano, I., Koehlen, S., Haase, H., Erb, G., Baltas, L.G., Rimbach, S., Wallwiener, D. and Bastert, G.
Journal of Cellular Biochemistry 64
: 171-181.
1 January 1997
Different actin affinities of human cardiac essential myosin light chain isoforms.
Morano, I. and Haase, H.
FEBS Letters 408
: 71-74.
1 January 1997
Expression of sense and naturally occurring antisense mrna of myosin heavy chain in rat heart tissue and cultivated cardiomyocytes.
Luther, H.P., Morwinski, R., Wallukat, G., Haase, H. and Morano, I.
Journal of Molecular and Cellular Cardiology 29
: 27-35.
1 January 1997
Hypertrophy of colonic smooth muscle: contractile proteins, shortening velocity, and regulation.
Siegman, M.J., Butler, T.M., Mooers, S.U., Trinklemulcahy, L., Narayan, S., Adam, L., Chacko, S., Haase, H. and Morano, I.
American Journal of Physiology Gastrointestinal and Liver Physiology 272
: G1571-G1580.
1 January 1997
In vitro motility assay of atrial and ventricular myosin from pig.
Svensson, C., Morano, I. and Arner, A.
Journal of Cellular Biochemistry 67
: 241-247.
1 January 1997
Influence of mechanical activity, adrenergic stimulation, and calcium on the expression of myosin heavy chains in cultivated neonatal cardiomyocytes.
Luther, H.P., Hille, S., Haase, H. and Morano, I.
Journal of Cellular Biochemistry 64
: 458-465.
1 January 1997
L- type calcium channels in insulin-secreting cells: biochemical characterization and phosphorylation in RINm5F cells.
Safayhi, H., Haase, H., Kramer, U., Bihlmayer, A., Roenfeldt, M., Ammon, H.P.T., Froschmayr, M., Cassidy, T.N., Morano, I., Ahlijanian, M.K. and Striessnig, J.
Molecular Endocrinology 11
: 619-629.
1 January 1997
Troponin I phosphorylation in cardiac myocytes from the spontaneously hypertensive rat: effect of beta-adrenergic stimulation.
McConnell, B.K., Schomisch-Moravec, C., Morano, I. and Bond, M.
American Journal of Physiology Heart and Circulatory Physiology 273
: H1440-H1451.
1 January 1997
beta1B subunit of voltage-dependent Ca2+ channels is predominant isoform expressed in human neuroblastoma cell line IMR32.
McEnery, M.W., Haase, H., Vance, C.L., Dubel, S.J., Morano, I., Copeland, T.D. and Choi, Y.
FEBS Letters 420
: 74-78.
1 January 1997
1996
Regulation of human heart contractility by essential myosin light chain isoforms.
Morano, M., Zacharzowski, U., Maier, M., Lange, P.E., Alexi-Meskishvili, V., Haase, H. and Morano, I.
Journal of Clinical Investigation 98
(2): 467-473.
15 July 1996
Alternative splicing of smooth muscle myosin heavy chains and its functional consequences.
Haase, H. and Morano, I.
Journal of Cellular Biochemistry 60
: 521-528.
1 January 1996
Contraction kinetics and myosin isoform composition in smooth muscle from hypertrophied rat urinary bladder.
Sjuve, R., Haase, H., Morano, I., Uvelius, B. and Arner, A.
Journal of Cellular Biochemistry 63
: 86-93.
1 January 1996
Expression of calcium channel subunits in the normal and diseased human myocardium.
Haase, H., Kresse, A., Hohaus, A., Schulte, H., Maier, M., Osterziel, K.J., Lange, P. and Morano, I.
Journal of Molecular Medicine 74
: 99-104.
1 January 1996
In-vivo phosphorylation of the cardiac L-type calcium channel beta-subunit in response to catecholamines.
Haase, H., Bartel, S., Karczewski, P., Morano, I. and Krause, E.G.
Molecular and Cellular Biochemistry 163-164
: 99-106.
1 January 1996
Molecular regulation of smooth muscle contraction.
Morano, I.
In:
Molecular Reviews in Cardiovascular Medicine.
Chapman & Hall, London [u.a.], 49-53.
1 January 1996
1995
Myosin light chain-actin interaction regulates cardiac contractility.
Morano, I., Ritter, O., Bonz, A., Timek, T., Vahl, C.F. and Michel, G.
Circulation Research 76
(5): 720-725.
May 1995
Function of C-protein and troponin I phosphorylation in the heart.
Bartel, S., Karczewski, P., Morano, I. and Krause, E.G.
Annals of the New York Academy of Sciences 752
: 243-245.
27 March 1995
Cyclic GMP-mediated phospholamban phosphorylation in intact cardiomyocytes.
Bartel, S., Willenbrock, R., Haase, H., Karczewski, P., Wallukat, G., Dietz, R. and Krause, E.G.
Biochemical and Biophysical Research Communications 214
(1): 75-80.
1 January 1995
Muskelphysiologie.
Morano, I.
In:
Handbuch Sporttraumatologie Sportorthopaedie. Funktionelle Anatomie, Diagnostik, Therapie.
Barth, Heidelberg, 15-41.
1 January 1995
Rate of active tension development from rigor in skinned atrial and ventricular cardiac fibres from swine following photolytic release of ATP from caged ATP.
Morano, I., Oesterman, A. and Arner, A.
Acta Physiologica Scandinavica 154
(3): 343-353.
1 January 1995
Steroid-hormone regulation of myosin subunit expression in smooth and cardiac muscle.
Calovini, T., Haase, H. and Morano, I.
Journal of Cellular Biochemistry 59
: 69-78.
1 January 1995
1994
Increased expression of endothelial constitutive nitric oxide synthase in rat aorta during pregnancy.
Goetz, R.M., Morano, I., Calovini, T., Studer, R. and Holtz, J.
Biochemical and Biophysical Research Communications 205
(1): 905-910.
30 November 1994
The failing human heart is unable to use the frank- starling mechanism.
Schwinger, R.H.G., Boehm, M., Koch, A., Schmidt, U., Morano, I., Eissner, H.J., Ueberfuhr, P., Reichart, B. and Erdmann, E.
Circulation Research 74
(5): 959-969.
1 May 1994
Titin, myosin light chains, and c-protein in the developing and failing human heart.
Morano, I., Haedicke, K., Grom, S., Koch, A., Schwinger, R.H.G., Boehm, M., Bartel, S., Erdmann, E. and Krause, E.G.
Journal of Molecular and Cellular Cardiology 26
(3): 361-368.
1 March 1994
Cardiac troponin I and tension generation of skinned fibres in the developing rat heart.
Bartel, S., Morano, I., Hunger, H.D., Katus, H., Pask, H., Karczewski, P. and Krause, E.G.
Journal of Molecular and Cellular Cardiology 26
: 1123-1131.
1 January 1994
Detection of skeletal muscle calcium channel subunits in cultured neonatal rat cardiac myocytes.
Haase, H., Wallukat, G., Flockerzi, V., Nastainczyk, W. and Hofmann, F.
Receptors & Channels 2
: 41-52.
1 January 1994
Inotropic effect of the cardioprotective agent 2,3- butanedione monoxime in failing and nonfailing human myocardium.
Schwinger, R.H.G., Boehm, M., Koch, A., Morano, I., Rueegg, J.C. and Erdmann, E.
Journal of Pharmacology and Experimental Therapeutics 269
: 778-786.
1 January 1994
1993
Phosphorylation of the L-type calcium channel beta subunit is involved in beta-adrenergic signal transduction in canine myocardium.
Haase, H., Karczewski, P., Beckert, R. and Krause, E.G.
FEBS Letters 335
(2): 217-222.
6 December 1993
Androgene regulieren die Transkriptionsrate der schweren alpha -Myosinkette im Herzen.
Kaling, M. and Morano, I.
In:
Zellulaere Mechanismen der Herz-Kreislaufregulation. Pharmakologische und klinische Konsequenzen.
Franz Gross Hypertonie Symposium, Schlosshotel Kronberg, 5.-7.Maerz 1992
.
Schattauer, Stuttgart, 151-158.
1 January 1993
Correlation of myosin heavy chain expression in the rat with cAMP in different models of hypertension-induced cardiac hypertrophy.
Morano, I., Adler, K., Weismann, K., Knorr, A., Erdmann, E. and Boehm, M.
Journal of Molecular and Cellular Cardiology 25
: 387-394.
1 January 1993
Expression of myosin heavy and light chains changes during pregnancy in the rat uterus.
Morano, I., Erb, G. and Sogl, B.
Pfluegers Archiv European Journal of Physiology 423
: 434-441.
1 January 1993
Myosin light chain phosphorylation and myosin isoenzyme expression regulate cardiac calcium sensitivity by modulation of cross-bridge cyclic kinetics.
Morano, I.
In:
Modulation of cardiac calcium sensitivity. A new approach to increasing the strenght of the heart.
Oxford University Press, Oxford, 178-197.
1 January 1993
1992
Molecular biology of smooth muscle.
Morano, I.L.
Journal of Hypertension 10
: 411-416.
1 May 1992
Counting target molecules by exponential polymerase chain reaction: copy number of mitochondrial DNA in rat tissues.
Wiesner, R.J., Ruegg, J.C. and Morano, I.
Biochemical and Biophysical Research Communications 183
(2): 553-559.
16 March 1992
Expression of myosin heavy and light chains and phosphorylation of the phosphorylatable myosin light chain in the heart ventricle of the European hamster during hibernation and in summer.
Morano, I., Adler, K., Agostini, B. and Hasselbach, W.
Journal of Muscle Research and Cell Motility 13
: 64-70.
1 February 1992
1991
The influence of cold stress on the myosin heavy chain expression of cardiac and smooth muscle in normotensive and spontaneously hypertensive female rats.
Adler, K., Boels, P., Ganten, U., Ganten, D. and Morano, I.
Circulation Research 69
(6): 1640-1644.
December 1991
Regulation of calcitonin gene-related peptide mRNA expression in the hearts of spontaneously hypertensive rats by testosterone.
Gillardon, F., Morano, I., Ganten, U. and Zimmermann, M.
Neuroscience Letters 125
: 77-80.
1 January 1991
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