Browse by Research Team

2024

Atypical KCNQ1/Kv7 channel function in a neonatal diabetes patient: hypersecretion preceded the failure of pancreatic β-cells.
Zhou, Z., Gong, M., Pande, A., Margineanu, A., Lisewski, U., Purfürst, B., Zhu, H., Liang, L., Jia, S., Froehler, S., Zeng, C., Kühnen, P., Khodaverdi, S., Krill, W., Röpke, T., Chen, W., Raile, K., Sander, M. and Izsvák, Z.
iScience 27 (7): 110291. 19 July 2024

2020

Hypochlorhydria reduces mortality in heart failure caused by Kcne2 gene deletion.
Lisewski, U., Köhncke, C., Schleussner, L., Purfürst, B., Lee, S.M., De Silva, A., Manville, R.W., Abbott, G.W. and Roepke, T.K.
FASEB Journal 34 (8): 10699-10719. August 2020

2019

The KCNE2 potassium channel β subunit is required for normal lung function and resilience to ischemia and reperfusion injury.
Zhou, L., Köhncke, C., Hu, Z., Roepke, T.K. and Abbott, G.W.
FASEB Journal 33 (9): 9762-9774. September 2019

Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular K(V) currents and predisposes to ventricular arrhythmia.
David, J.P., Lisewski, U., Crump, S.M., Jepps, T.A., Bocksteins, E., Wilck, N., Lossie, J., Roepke, T.K., Schmitt, N. and Abbott, G.W.
FASEB Journal 33 (2): 2537-2552. February 2019

2016

Pericardial tamponade in an adult suffering from acute mumps infection.
Kahlfuss, S., Flieger, R.R., Mankertz, A., Yilmaz, K. and Roepke, T.K.
Case Reports in Medicine 2016 : 7980936. 12 October 2016

Diagnosis and treatment of cardiac echinococcosis.
Kahlfuss, S., Flieger, R.R., Roepke, T.K. and Yilmaz, K.
Heart 102 (17): 1348-1353. September 2016

Evidence for MOR on cell membrane, sarcoplasmatic reticulum and mitochondria in left ventricular myocardium in rats.
Treskatsch, S., Shaqura, M., Dehe, L., Roepke, T.K., Shakibaei, M., Schaefer, M. and Mousa, S.A.
Heart and Vessels 31 (8): 1380-1388. August 2016

Increased aldosterone-dependent Kv1.5 recycling predisposes to pacing-induced atrial fibrillation in Kcne3-/- mice.
Lisewski, U., Koehncke, C., Wilck, N., Buschmeyer, B., Pieske, B. and Roepke, T.K.
FASEB Journal 30 (7): 2476-2489. July 2016

Muscle RING-finger 2 and 3 maintain striated-muscle structure and function.
Lodka, D., Pahuja, A., Geers-Knörr, C., Scheibe, R., Nowak, M., Hamati, J., Köhncke, C., Purfürst, B., Kanashova, T., Schmidt, S., Glass, D.J., Morano, I., Heuser, A., Kraft, T., Bassel-Duby, R., Olson, E.N., Dittmar, G., Sommer, T. and Fielitz, J.
Journal of Cachexia Sarcopenia and Muscle 7 (2): 165-180. May 2016

KCNE2 and gastric cancer: bench to bedside.
Abbott, G.W. and Roepke, T.K.
Oncotarget 7 (14): 17286-17287. 5 April 2016

Kcne2 deletion causes early-onset nonalcoholic fatty liver disease via iron deficiency anemia.
Lee, S.M., Nguyen, D., Anand, M., Kant, R., Koehncke, C., Lisewski, U., Roepke, T.K., Hu, Z. and Abbott, G.W.
Scientific Reports 6 : 23118. 17 March 2016

Maximizing information from routine staging computed tomography in functional neuroendocrine neoplasms: are there findings indicating the presence of carcinoid heart disease?
Baur, A.D.J., Kunz, F., Schwenke, C., Pschowski, R., Roepke, T.K., Pavel, M. and Denecke, T.
Journal of Computer Assisted Tomography 40 (2): 277-282. March 2016

Cellular localization and adaptive changes of the cardiac delta opioid receptor system in an experimental model of heart failure in rats.
Treskatsch, S., Feldheiser, A., Shaqura, M., Dehe, L., Habazettl, H., Roepke, T.K., Shakibaei, M., Schaefer, M., Spies, C.D. and Mousa, S.A.
Heart and Vessels 31 (2): 241-250. February 2016

2015

Upregulation of the kappa opioidergic system in left ventricular rat myocardium in response to volume overload : adaptive changes of the cardiac kappa opioid system in heart failure.
Treskatsch, S., Shaqura, M., Dehe, L., Feldheiser, A., Roepke, T.K., Shakibaei, M., Spies, C.D., Schäfer, M. and Mousa, S.A.
Pharmacological Research 102 : 33-41. December 2015

Ultrastructural changes associated with myocardial apoptosis, in failing rat hearts induced by volume overload.
Treskatsch, S., Shakibaei, M., Feldheiser, A., Shaqura, M., Dehe, L., Roepke, T.K., Spies, C., Schaefer, M. and Mousa, S.A.
International Journal of Cardiology 197 : 327-332. 15 October 2015

2014

KCNQ1, KCNE2, and Na(+)-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability.
Abbott, G.W, Tai, K.K., Neverisky, D.L., Hansler, A., Hu, Z., Roepke, T.K., Lerner, D.J., Chen, Q., Liu, L., Zupan, B., Toth, M., Haynes, R., Huang, X., Demirbas, D., Buccafusca, R., Gross, S.S., Kanda, V.A. and Berry, G.T.
Science Signaling 7 (315): ra22. 4 March 2014

Glucagonoma-induced acute heart failure.
Zhang, K., Lehner, L.J., Praeger, D., Baumann, G., Knebel, F., Quinkler, M. and Roepke, T.K.
Endocrinology Diabetes and Metabolism Case Reports 2014 : 140061. 2014

2013

Isolation and kv channel recordings in murine atrial and ventricular cardiomyocytes.
Koehncke, C., Lisewski, U., Schleussner, L., Gaertner, C., Reichert, S. and Roepke, T.K.
Journal of Visualized Experiments (73): e50145. 12 March 2013

2011

KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium.
Roepke, T.K., Kanda, V.A., Purtell, K., King, E.C., Lerner, D.J. and Abbott, G.W.
FASEB Journal 25 (12): 4264-4273. December 2011

Genetic dissection reveals unexpected influence of beta subunits on KCNQ1 K+ channel polarized trafficking in vivo.
Roepke, T.K., King, E.C., Purtell, K., Kanda, V.A., Lerner, D.J. and Abbott, G.W.
FASEB Journal 25 (2): 727-736. February 2011

2010

Cardiac arrhythmia and thyroid dysfunction: a novel genetic link.
Purtell, K., Roepke, T.K. and Abbott, G.W.
International Journal of Biochemistry and Cell Biology 42 (11): 1767-1770. November 2010

Targeted deletion of Kcne2 causes gastritis cystica profunda and gastric neoplasia.
Roepke, T.K., Purtell, K., King, E.C., La Perle, K.M., Lerner, D.J. and Abbott, G.W.
PLoS ONE 5 (7): e11451. 6 July 2010

2009

Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis.
Roepke, T.K., King, E.C., Reyna-Neyra, A., Paroder, M., Purtell, K., Koba, W., Fine, E., Lerner, D.J., Carrasco, N. and Abbott, G.W.
Nature Medicine 15 (10): 1186-1194. October 2009

MinK-dependent internalization of the IKs potassium channel.
Xu, X., Kanda, V.A., Choi, E., Panaghie, G., Roepke, T.K., Gaeta, S.A., Christini, D.J., Lerner, D.J. and Abbott, G.W.
Cardiovascular Research 82 (3): 430-438. 1 June 2009

HERG biosynthesis: the positive influence of negative charge.
Abbott, G.W. and Roepke, T.K.
American Journal of Physiology Heart and Circulatory Physiology 296 (5): H1211-H1212. May 2009

Regulation of the Kv2.1 potassium channel by MinK and MiRP1.
McCrossan, Z.A., Roepke, T.K., Lewis, A., Panaghie, G. and Abbott, G.W.
Journal of Membrane Biology 228 (1): 1-14. March 2009

2008

Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f).
Roepke, T.K., Kontogeorgis, A., Ovanez, C., Xu, X., Young, J.B., Purtell, K., Goldstein, P.A., Christini, D.J., Peters, N.S., Akar, F.G., Gutstein, D.E., Lerner, D.J. and Abbott, G.W.
FASEB Journal 22 (10): 3648-3660. 1 October 2008

Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.
Yang, L., Soonpaa, M.H., Adler, E.D., Roepke, T.K., Kattman, S.J., Kennedy, M., Henckaerts, E., Bonham, K., Abbott, G.W., Linden, R.M., Field, L.J. and Keller, G.M.
Nature 453 (7194): 524-528. 22 May 2008

A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance.
Gordon, E., Panaghie, G., Deng, L., Bee, K.J., Roepke, T.K., Krogh-Madsen, T., Christini, D.J., Ostrer, H., Basson, C.T., Chung, W. and Abbott, G.W.
Cardiovascular Research 77 (1): 98-106. January 2008

2007

Impact of ancillary subunits on ventricular repolarization.
Abbott, G.W., Xu, X. and Roepke, T.K.
Journal of Electrocardiology 40 (6 Suppl): S42-S46. November 2007

2006

The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion.
Roepke, T.K., Anantharam, A., Kirchhoff, P., Busque, S.M., Young, J.B., Geibel, J.P., Lerner, D.J. and Abbott, G.W.
Journal of Biological Chemistry 281 (33): 23740-23747. 18 August 2006

Calcium-sensing receptor abrogates secretagogue- induced increases in intestinal net fluid secretion by enhancing cyclic nucleotide destruction.
Geibel, J., Sritharan, K., Geibel, R., Geibel, P., Persing, J.S., Seeger, A., Roepke, T.K., Deichstetter, M., Prinz, C., Cheng, S.X., Martin, D. and Hebert, S.C.
Proceedings of the National Academy of Sciences of the United States of America 103 (25): 9390-9397. 20 June 2006

Endogenous KCNE subunits govern Kv2.1 K+ channel activation kinetics in Xenopus oocyte studies.
Gordon, E., Roepke, T.K. and Abbott, G.W.
Biophysical Journal 90 (4): 1223-1231. 15 February 2006

Pharmacogenetics and cardiac ion channels.
Roepke, T.K. and Abbott, G.W.
Vascular Pharmacology 44 (2): 90-106. February 2006