Browse by Research Team

Article

HIF prolyl hydroxylase 2/3 deletion disrupts astrocytic integrity and exacerbates neuroinflammation.
Rosiewicz, K.S., Muinjonov, B., Kunz, S., Radbruch, H., Chen, J., Jüttner, R., Kerkering, J., Ucar, J., Crowley, T., Wielockx, B., Paul, F., Alisch, M. and Siffrin, V.
Glia 71 (8): 2024-2044. August 2023

iPSC-derived reactive astrocytes from patients with multiple-sclerosis protect cocultured neurons in inflammatory conditions.
Kerkering, J., Muinjonov, B., Rosiewicz, K.S., Diecke, S., Biese, C., Schiweck, J., Chien, C., Zocholl, D., Conrad, T., Paul, F., Alisch, M. and Siffrin, V.
Journal of Clinical Investigation 133 (13): e164637. 3 July 2023

Inflammatory cytokines associated with multiple sclerosis directly induce alterations of neuronal cytoarchitecture in human neurons.
Meyer-Arndt, L., Kerkering, J., Kuehl, T., Gil Infante, A., Paul, F., Rosiewicz, K.S., Siffrin, V. and Alisch, M.
Journal of Neuroimmune Pharmacology 18 (1-2): 145-159. June 2023

Mepolizumab as an effective treatment in a case of hypophysitis in eosinophilic granulomatosis with polyangiitis.
Chen, J., Alexander, T., Walter-Rittel, T., Ziagaki, A. and Siffrin, V.
Therapeutic Advances in Neurological Disorders 16 : 17562864231182519. 2023

Pentafluorosulfanyl (SF(5)) as a superior (19)F magnetic resonance reporter group: signal detection and biological activity of teriflunomide derivatives.
Prinz, C., Starke, L., Ramspoth, T.F., Kerkering, J., Martos Riaño, V., Paul, J., Neuenschwander, M., Oder, A., Radetzki, S., Adelhoefer, S., Ramos Delgado, P., Aravina, M., Millward, J.M., Fillmer, A., Paul, F., Siffrin, V., von Kries, J.P., Niendorf, T., Nazaré, M. and Waiczies, S.
ACS Sensors 6 (11): 3948–3956. 26 November 2021

Lymphocyte access to lymphoma is impaired by high endothelial venule regression.
Menzel, L., Zschummel, M., Crowley, T., Franke, V., Grau, M., Ulbricht, C., Hauser, A., Siffrin, V., Bajénoff, M., Acton, S.E., Akalin, A., Lenz, G., Willimsky, G., Höpken, U.E. and Rehm, A.
Cell Reports 37 (4): 109878. 26 October 2021

Identification of the gliogenic state of human neural stem cells to optimize in vitro astrocyte differentiation.
Alisch, M., Kerkering, J., Crowley, T., Rosiewicz, K., Paul, F. and Siffrin, V.
Journal of Neuroscience Methods 361 : 109284. 1 September 2021

Epigallocatechin gallate in relapsing-remitting multiple sclerosis: a randomized, placebo-controlled trial.
Bellmann-Strobl, J., Paul, F., Wuerfel, J., Dörr, J., Infante-Duarte, C., Heidrich, E., Körtgen, B., Brandt, A., Pfüller, C., Radbruch, H., Rust, R., Siffrin, V., Aktas, O., Heesen, C., Faiss, J., Hoffmann, F., Lorenz, M., Zimmermann, B., Groppa, S., Wernecke, K.D. and Zipp, F.
Neurology Neuroimmunology & Neuroinflammation 8 (3): e981. May 2021

Neutrophil gelatinase-associated lipocalin protects from ANCA-induced GN by inhibiting T(H)17 immunity.
Schreiber, A., Rousselle, A., Klocke, J., Bachmann, S., Popovic, S., Bontscho, J., Schmidt-Ott, K.M., Siffrin, V., Jerke, U., Ashraf, M.I., Panzer, U. and Kettritz, R.
Journal of the American Society of Nephrology 31 (7): 1569-1584. July 2020

Comparison of RNA isolation procedures for analysis of adult murine brain and spinal cord astrocytes.
Rosiewicz, K.S., Crowley, T., Saher, G., Kerkering, J., Alisch, M. and Siffrin, V.
Journal of Neuroscience Methods 333 : 108545. 1 March 2020

Disease modification in multiple sclerosis by flupirtine - results of a randomized placebo controlled phase II trial.
Dörr, J., Wernecke, K.D., Würfel, J., Bellmann-Strobl, J., Siffrin, V., Sättler, M.B., Simons, M., Linsa, A., Tumani, H. and Paul, F.
Frontiers in Neurology 9 : 842. October 2018

CCR7 on CD4(+) T cells plays a crucial role in the induction of experimental autoimmune encephalomyelitis.
Belikan, P., Bühler, U., Wolf, C., Pramanik, G.K., Gollan, R., Zipp, F. and Siffrin, V.
Journal of Immunology 200 (8): 2554-2562. 15 April 2018

Phenotype of antigen unexperienced T(H) cells in the inflamed central nervous system in experimental autoimmune encephalomyelitis.
Franck, S., Paterka, M., Birkenstock, J., Zipp, F., Siffrin, V. and Witsch, E.
Journal of Neuroimmune Pharmacology 12 (2): 305-313. June 2017

Role of IL-17-producing lymphocytes in severity of multiple sclerosis upon natalizumab treatment.
Bühler, U., Fleischer, V., Luessi, F., Rezk, A., Belikan, P., Graetz, C., Gollan, R., Wolf, C., Lutz, J., Bar-Or, A., Siffrin, V. and Zipp, F.
Multiple Sclerosis Journal 23 (4): 567-576. 1 April 2017

Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis.
Paterka, M., Voss, J.O., Werr, J., Reuter, E., Franck, S., Leuenberger, T., Herz, J., Radbruch, H., Bopp, T., Siffrin, V. and Zipp, F.
Journal of Autoimmunity 76 : 108-114. January 2017

PML risk stratification using anti-JCV antibody index and L-selectin.
Schwab, N., Schneider-Hohendorf, T., Pignolet, B., Spadaro, M., Görlich, D., Meinl, I., Windhagen, S., Tackenberg, B., Breuer, J., Cantó, E., Kümpfel, T., Hohlfeld, R., Siffrin, V., Luessi, F., Posevitz-Fejfár, A., Montalban, X., Meuth, S.G., Zipp, F., Gold, R., Du Pasquier, R.A., Kleinschnitz, C., Jacobi, A., Comabella, M., Bertolotto, A., Brassat, D. and Wiendl, H.
Multiple Sclerosis Journal 22 (8): 1048-1060. July 2016

Flow cytometric analysis of T cell/monocyte ratio in clinically isolated syndrome identifies patients at risk of rapid disease progression.
Nemecek, A., Zimmermann, H., Rübenthaler, J., Fleischer, V., Paterka, M., Luessi, F., Müller-Forell, W., Zipp, F. and Siffrin, V.
Multiple Sclerosis Journal 22 (4): 483-493. April 2016

In vivo and in vitro effects of multiple sclerosis immunomodulatory therapeutics on glutamatergic excitotoxicity.
Luchtman, D., Gollan, R., Ellwardt, E., Birkenstock, J., Robohm, K., Siffrin, V. and Zipp, F.
Journal of Neurochemistry 136 (5): 971-980. March 2016

Gatekeeper role of brain antigen-presenting CD11c(+) cells in neuroinflammation.
Paterka, M., Siffrin, V., Voss, J.O., Werr, J., Hoppmann, N., Gollan, R., Belikan, P., Bruttger, J., Birkenstock, J., Jung, S., Esplugues, E., Yogev, N., Flavell, R.A., Bopp, T. and Zipp, F.
EMBO Journal 35 (1): 89-101. 4 January 2016

Role of sortilin in models of autoimmune neuroinflammation.
Reuter, E., Weber, J., Paterka, M., Ploen, R., Breiderhoff, T., van Horssen, J., Willnow, T.E., Siffrin, V. and Zipp, F.
Journal of Immunology 195 (12): 5762-5769. 15 December 2015

FRET based ratiometric Ca(2+) imaging to investigate immune-mediated neuronal and axonal damage processes in experimental autoimmune encephalomyelitis.
Siffrin, V., Birkenstock, J., Luchtmann, D.W., Gollan, R., Baumgart, J., Niesner, R.A., Griesbeck, O. and Zipp, F.
Journal of Neuroscience Methods 249 : 8-15. 15 July 2015

New candidates for CD4 T cell pathogenicity in experimental neuroinflammation and multiple sclerosis.
Hoppmann, N., Graetz, C., Paterka, M., Poisa-Beiro, L., Larochelle, C., Hasan, M., Lill, C.M., Zipp, F. and Siffrin, V.
Brain 138 (Pt 4): 902-917. April 2015

Cross-recognition of a myelin peptide by CD8(+) T cells in the CNS is not sufficient to promote neuronal damage.
Reuter, E., Gollan, R., Grohmann, N., Paterka, M., Salmon, H., Birkenstock, J., Richers, S., Leuenberger, T., Brandt, A.U., Kuhlmann, T., Zipp, F. and Siffrin, V.
Journal of Neuroscience 35 (12): 4837-4850. 25 March 2015

MHCII-independent CD4(+) T cells protect injured CNS neurons via IL-4.
Walsh, J.T., Hendrix, S., Boato, F., Smirnov, I., Zheng, J., Lukens, J.R., Gadani, S., Hechler, D., Gölz, G., Rosenberger, K., Kammertöns, T., Vogt, J., Vogelaar, C., Siffrin, V., Radjavi, A., Fernandez-Castaneda, A., Gaultier, A., Gold, R., Kanneganti, T.D., Nitsch, R., Zipp, F. and Kipnis, J.
Journal of Clinical Investigation 125 (2): 699-714. 2 February 2015

The impact of isolated lesions on white-matter fiber tracts in multiple sclerosis patients.
Droby, A., Fleischer, V., Carnini, M., Zimmermann, H., Siffrin, V., Gawehn, J., Erb, M., Hildebrandt, A., Baier, B. and Zipp, F.
NeuroImage: Clinical 8 : 110-116. 2015

Cardiotoxicity of mitoxantrone treatment in a german cohort of 639 multiple sclerosis patients.
Fleischer, V., Salmen, A., Kollar, S., Weyer, V., Siffrin, V., Chan, A., Zipp, F. and Luessi, F.
Journal of Clinical Neurology 10 (4): 289-295. October 2014

Modulation of dendritic cell immunobiology via inhibition of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase.
Leuenberger, T., Pfueller, C.F., Luessi, F., Bendix, I., Paterka, M., Prozorovski, T., Treue, D., Luenstedt, S., Herz, J., Siffrin, V., Infante-Duarte, C., Zipp, F. and Waiczies, S.
PLoS ONE 9 (7): e100871. 11 July 2014

Experimental applications of TNF-reporter mice with far-red fluorescent label.
Shebzukhov, Y.V., Kuchmiy, A.A., Kruglov, A.A., Zipp, F., Siffrin, V. and Nedospasov, S.A.
Methods in Molecular Biology 1155 : 151-162. 10 April 2014

How to treat tumefactive demyelinating disease?
Siffrin, V., Müller-Forell, W., von Pein, H. and Zipp, F.
Multiple Sclerosis Journal 20 (5): 631-633. April 2014

Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.
Langenfurth, A., Rinnenthal, J.L., Vinnakota, K., Prinz, V., Carlo, A.S., Stadelmann, C., Siffrin, V., Peaschke, S., Endres, M., Heppner, F., Glass, R., Wolf, S.A. and Kettenmann, H.
Journal of Neuroscience Research 92 (3): 275-286. March 2014

Microglial activation milieu controls regulatory T cell responses.
Ebner, F., Brandt, C., Thiele, P., Richter, D., Schliesser, U., Siffrin, V., Schueler, J., Stubbe, T., Ellinghaus, A., Meisel, C., Sawitzki, B. and Nitsch, R.
Journal of Immunology 191 (11): 5594-5602. 1 December 2013

The role of CD8(+) T cells and their local interaction with CD4(+) T cells in myelin oligodendrocyte glycoprotein(35-55)-induced experimental autoimmune encephalomyelitis.
Leuenberger, T., Paterka, M., Reuter, E., Herz, J., Niesner, R.A., Radbruch, H., Bopp, T., Zipp, F. and Siffrin, V.
Journal of Immunology 191 (10): 4960-4968. 15 November 2013

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

Nature Genetics 45 (11): 1353-1360. November 2013

Parallelized TCSPC for dynamic intravital fluorescence lifetime imaging: quantifying neuronal dysfunction in neuroinflammation.
Rinnenthal, J.L., Börnchen, C., Radbruch, H., Andresen, V., Mossakowski, A., Siffrin, V., Seelemann, T., Spiecker, H., Moll, I., Herz, J., Hauser, A.E., Zipp, F., Behne, M.J. and Niesner, R.
PLoS ONE 8 (4): e60100. 16 April 2013

Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis.
Jolivel, V., Luessi, F., Masri, J., Kraus, S.H.P., Hubo, M., Poisa-Beiro, L., Klebow, S., Paterka, M., Yogev, N., Tumani, H., Furlan, R., Siffrin, V., Jonuleit, H., Zipp, F. and Waisman, A.
Brain 136 (4): 1048-1066. 1 April 2013

Two-photon imaging of immune cells in neural tissue.
Niesner, R., Siffrin, V. and Zipp, F.
Cold Spring Harbor Protocols 2013 (3): 224-230. 1 March 2013

BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions.
Kipp, M., Gingele, S., Pott, F., Clarner, T., van der Valk, P., Denecke, B., Gan, L., Siffrin, V., Zipp, F., Dreher, W., Baumgartner, W., Pfeifenbring, S., Godbout, R., Amor, S. and Beyer, C.
Brain, Behavior and Immunity 25 (8): 1554-1568. November 2011

In vivo imaging of lymphocytes in the CNS reveals different behaviour of naive T cells in health and autoimmunity.
Herz, J., Paterka, M., Niesner, R.A., Brandt, A.U., Siffrin, V., Leuenberger, T., Birkenstock, J., Mossakowski, A., Glumm, R., Zipp, F. and Radbruch, H.
Journal of Neuroinflammation 8 (1): 131. 6 October 2011

In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis.
Siffrin, V., Radbruch, H., Glumm, R., Niesner, R., Paterka, M., Herz, J., Leuenberger, T., Lehmann, S.M., Luenstedt, S., Rinnenthal, J.L., Laube, G., Luche, H., Lehnardt, S., Fehling, H.J., Griesbeck, O. and Zipp, F.
Immunity 33 (3): 424-436. 24 September 2010

MAPK3 deficiency drives autoimmunity via dendritic cell arming.
Bendix, I., Pfueller, C.F., Leuenberger, T., Glezeva, N., Siffrin, V., Mueller, Y., Prozorovski, T., Hansen, W., Schulze-Topphoff, U., Loddenkemper, C., Zipp, F. and Waiczies, S.
European Journal of Immunology 40 (5): 1486-1495. May 2010

Expanding two-photon intravital microscopy to the infrared by means of optical parametric oscillator.
Herz, J., Siffrin, V., Hauser, A.E., Brandt, A.U., Leuenberger, T., Radbruch, H., Zipp, F. and Niesner, R.A.
Biophysical Journal 98 (4): 715-723. 17 February 2010

Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death.
Meuth, S.G., Herrmann, A.M., Simon, O.J., Siffrin, V., Melzer, N., Bittner, S., Meuth, P., Langer, H.F., Hallermann, S., Boldakowa, N., Herz, J., Munsch, T., Landgraf, P., Aktas, O., Heckmann, M., Lessmann, V., Budde, T., Kieseier, B.C., Zipp, F. and Wiendl, H.
Journal of Neuroscience 29 (49): 15397-15409. 9 December 2009

Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.
Schulze-Topphoff, U., Prat, A., Prozorovski, T., Siffrin, V., Paterka, M., Herz, J., Bendix, I., Ifergan, I., Schadock, I., Mori, M.A., Van Horssen, J., Schroeter, F., Smorodchenko, A., Han, M.H., Bader, M., Steinman, L., Aktas, O. and Zipp, F.
Nature Medicine 15 (7): 788-793. July 2009

Differential immune cell dynamics in the CNS cause CD4+ T cell compartmentalization.
Siffrin, V., Brandt, A.U., Radbruch, H., Herz, J., Boldakowa, N., Leuenberger, T., Werr, J., Hahner, A., Schulze-Topphoff, U., Nitsch, R. and Zipp, F.
Brain 132 (5): 1247-1258. May 2009

Lipopolysaccharide injection induces relapses of experimental autoimmune encephalomyelitis in nontransgenic mice via bystander activation of autoreactive CD4+ cells.
Nogai, A., Siffrin, V., Bonhagen, K., Pfueller, C.F., Hohnstein, T., Volkmer-Engert, R., Brueck, W., Stadelmann, C. and Kamradt, T.
Journal of Immunology 175 (2): 959-966. 15 July 2005

Conference or Workshop Item

A new light source for multimodal multiphoton microscopy including CARS.
Rimke, I., Siffrin, V., Niesner, R., Leuenberger, T., Zipp, F., Buttnera, E. and Stibenza, G.
In: Conference on Multiphoton Microscopy in the Biomedical Sciences IX, JAN 25-27, 2009 , San Jose, CA, USA. 13 February 2009

Review

Neurodegeneration in multiple sclerosis: novel treatment strategies.
Luessi, F., Siffrin, V. and Zipp, F.
Expert Review of Neurotherapeutics 12 (9): 1061-1077. September 2012

Neurodegeneration in autoimmune CNS inflammation.
Herz, J., Zipp, F. and Siffrin, V.
Experimental Neurology 225 (1): 9-17. September 2010

Multiple sclerosis - candidate mechanisms underlying CNS atrophy.
Siffrin, V., Vogt, J., Radbruch, H., Nitsch, R. and Zipp, F.
Trends in Neurosciences 33 (4): 202-210. April 2010

New insights into adaptive immunity in chronic neuroinflammation.
Siffrin, V., Brandt, A.U., Herz, J. and Zipp, F.
Advances in Immunology 96 : 1-40. 2007

Letter

Reevaluating the relevance of F-FDG PET findings for diagnosis of neurosarcoidosis: a case series.
Chen, J., Metzger, G., Furth, C., Bohner, G. and Siffrin, V.
Neurological Research and Practice 6 (1): 12. 25 January 2024

Editorial

Complicated monkeypox infection in a patient with multiple sclerosis and fingolimod treatment.
Müller-Jensen, L., Kriedemann, H., Anvari, K., Huehnchen, P. and Siffrin, V.
Neurology 100 (14): 670-671. 4 April 2023