Browse by Journal Title

Article

Update and European consensus on a patient-centered core outcome set for multiple myeloma in clinical practice and research.
Oerlemans, S., De Rooij, B.H., Bennink, C., Bullinger, L., Broijl, A., D'Agostino, M., Laane, E., Lupo-Stanghellini, M.T., Perrot, A., Wester, R., Cursaru, V., Scheurer, H., Vesseur, J., Dalal, M., Sen, R., Stamm, T., Ludwig, H. and Sonneveld, P.
Haematologica 109 (6): 1956-1959. June 2024

The diversity of the microbiome impacts chronic lymphocytic leukemia development in mice and humans.
Faitova, T., Coelho, M., Da Cunha-Bang, C., Ozturk, S., Kartal, E., Bork, P., Seiffert, M. and Niemann, C.U.
Haematologica 9 May 2024 (In Press)

HLA-C*04:09N is expressed at the cell surface and triggers peptide-specific T-cell activation.
Welters, C., Welters, M.L., Stadler, S., Bullinger, L., Strobel, J., Hackstein, H., Dhamodaran, A., Blankenstein, T. and Hansmann, L.
Haematologica 109 (4): 1121-1127. April 2024

Impact of trisomy 19 on outcome according to genetic makeup in patients with acute myeloid leukemia.
Kayser, S., Martínez-Cuadrón, D., Rodriguez-Veiga, R., Hänel, M., Tormo, M., Schäfer-Eckart, K., Botella, C., Stölzel, F., Del Castillo, T.B., Keller, U., Rodriguez-Medina, C., Held, G., Amigo, M.L., Schliemann, C., Colorado, M., Kaufmann, M., Garcia, M.B., Krause, S.W., Görner, M., Jost, E., Steffen, B., Zukunft, S., Platzbecker, U., Ho, A.D., Baldus, C.D., Serve, H., Müller-Tidow, C., Thiede, C., Bornhäuser, M., Montesinos, P., Röllig, C. and Schlenk, R.F.
Haematologica 108 (8): 2059-2066. August 2023

Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas.
Lopez, C., Schleussner, N., Bernhart, S.H., Kleinheinz, K., Sungalee, S., Sczakiel, H.L., Kretzmer, H., Toprak, U.H., Glaser, S., Wagener, R., Ammerpohl, O., Bens, S., Giefing, M., Sanchez, J.C.G., Apic, G., Hubschmann, D., Janz, M., Kreuz, M., Mottok, A., Müller, J.M., Seufert, J., Hoffmann, S., Korbel, J.O., Russell, R.B., Schule, R., Trumper, L., Klapper, W., Radlwimmer, B., Lichter, P., Kuppers, R., Schlesner, M., Mathas, S. and Siebert, R.
Haematologica 108 (2): 543-554. 1 February 2023

Small molecule SUMO inhibition for biomarker-informed B-cell lymphoma therapy.
Demel, U.M., Wirth, M., Yousefian, S., Zhang, L., Isaakidis, K., Dönig, J., Böger, M., Singh, N., Köse, H., Haas, S., Müller, S., Schick, M. and Keller, U.
Haematologica 108 (2): 555-567. February 2023

The retinoic acid receptor co-factor NRIP1 is uniquely upregulated and represents a therapeutic target in acute myeloid leukemia with chromosome 3q rearrangements.
Grasedieck, S., Cabantog, A., MacPhee, L., Im, J., Ruess, C., Demir, B., Sperb, N., Rücker, F.G., Döhner, K., Herold, T., Pollack, J.R., Bullinger, L., Rouhi, A. and Kuchenbauer, F.
Haematologica 107 (8): 1758-1772. August 2022

Acute myeloid leukemia: negative prognostic impact of early blast persistence can be in part overcome by a later remission prior to post-induction therapy.
Ihlow, J., Gross, S., Busack, L., Flörcken, A., Jesse, J., Schwarz, M., Neuendorff, N.R., von Brünneck, A.C., Anagnostopoulos, I., Türkmen, S., Blau, I.W., Burmeister, T., Horst, D., Bullinger, L. and Westermann, J.
Haematologica 107 (8): 1773-1785. August 2022

B cell antigen receptor expression and phosphatidylinositol 3-kinase signaling regulate genesis and maintenance of mouse chronic lymphocytic leukemia.
Schmid, V.K., Khadour, A., Ahmed, N., Brandl, C., Nitschke, L., Rajewsky, K., Jumaa, H. and Hobeika, E.
Haematologica 107 (8): 1796-1814. August 2022

Micro-RNA networks in T-cell prolymphocytic leukemia reflect T-cell activation and shape DNA damage response and survival pathways.
Braun, T., Glass, M., Wahnschaffe, L., Otte, M., Mayer, P., Franitza, M., Altmüller, J., Hallek, M., Hüttelmaier, S., Schrader, A. and Herling, M.
Haematologica 107 (1): 187-200. January 2022

Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide - an international collaborative study.
Kayser, S., Schlenk, R.F., Lebon, D., Carre, M., Götze, K.S., Stölzel, F., Berceanu, A., Schäfer-Eckart, K., Peterlin, P., Hicheri, Y., Rahme, R., Raffoux, E., Chermat, F., Krause, S.W., Aulitzky, W.E., Rigaudeau, S., Noppeney, R., Berthon, C., Görner, M., Jost, E., Carassou, P., Keller, U., Orvain, C., Braun, T., Saillard, C., Arar, A., Kunzmann, V., Wemeau, M., De Wit, M., Niemann, D., Bonmati, C., Schwänen, C., Abraham, J., Aljijakli, A., Haiat, S., Krämer, A., Reichle, A., Gnadler, M., Willekens, C., Spiekermann, K., Hiddemann, W., Müller-Tidow, C., Thiede, C., Röllig, C., Serve, H., Bornhäuser, M., Baldus, C.D., Lengfelder, E., Fenaux, P., Platzbecker, U. and Adès, L.
Haematologica 106 (12): 3100-3106. December 2021

Prognostic and predictive role of gene mutations in chronic lymphocytic leukemia: results from the pivotal phase III study COMPLEMENT1.
Tausch, E., Beck, P., Schlenk, R.F., Jebaraj, B.M.C., Dolnik, A., Yosifov, D.Y., Hillmen, P., Offner, F., Janssens, A., Babu, K.G., Grosicki, S., Mayer, J., Panagiotidis, P., McKeown, A., Gupta, I.V., Skorupa, A., Pallaud, C., Bullinger, L., Mertens, D., Döhner, H. and Stilgenbauer, S.
Haematologica 105 (10): 2440-2447. October 2020

Endothelial damage and dysfunction in acute graft-versus-host disease.
Cordes, S., Mokhtari, Z., Bartosova, M., Mertlitz, S., Riesner, K., Shi, Y., Mengwasser, J., Kalupa, M., McGeary, A., Schleifenbaum, J., Schrezenmeier, J., Bullinger, L., Diaz-Ricart, M., Palomo, M., Carrreras, E., Beutel, G., Schmitt, C.P., Beilhack, A. and Penack, O.
Haematologica 106 (8): 2147-2160. 1 August 2020

Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1-regulated transcription.
Edelmann, J., Holzmann, K., Tausch, E., Saunderson, E.A., Jebaraj, B.M.C., Steinbrecher, D., Dolnik, A., Blätte, T.J., Landau, D.A., Saub, J., Estenfelder, S., Ibach, S., Cymbalista, F., Leblond, V., Delmer, A., Bahlo, J., Robrecht, S., Fischer, K., Goede, V., Bullinger, L., Wu, C.J., Mertens, D., Ficz, G., Gribben, J.G., Hallek, M., Döhner, H. and Stilgenbauer, S.
Haematologica 105 (5): 1379-1390. May 2020

Predicting sinusoidal obstruction syndrome after allogeneic stem cell transplantation with the EASIX biomarker panel.
Jiang, S., Penack, O., Terzer, T., Schult, D., Majer-Lauterbach, J., Radujkovic, A., Blau, I.W., Bullinger, L., Müller-Tidow, C., Dreger, P. and Luft, T.
Haematologica 106 (2): 446-453. February 2020

Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia.
Schneider, E., Staffas, A., Röhner, L., Malmberg, E.D., Ashouri, A., Krowiorz, K., Pochert, N., Miller, C., Wei, S.Y., Arabanian, L., Buske, C., Döhner, H., Bullinger, L., Fogelstrand, L., Heuser, M., Döhner, K., Xiang, P., Ruschmann, J., Petriv, O.I., Heravi-Moussavi, A., Hansen, C.L., Hirst, M., Humphries, R.K., Rouhi, A., Palmqvist, L. and Kuchenbauer, F.
Haematologica 103 (2): 246-255. February 2018

Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia.
Hirsch, S., Blätte, T.J., Grasedieck, S., Cocciardi, S., Rouhi, A., Jongen-Lavrencic, M., Paschka, P., Krönke, J., Gaidzik, V.I., Döhner, H., Schlenk, R.F., Kuchenbauer, F., Döhner, K., Dolnik, A. and Bullinger, L.
Haematologica 102 (12): 2039-2047. December 2017

IFNα-mediated remodeling of endothelial cells in the bone marrow niche.
Prendergast, Á.M., Kuck, A., van Essen, M., Haas, S., Blaszkiewicz, S. and Essers, M.A.G.
Haematologica 102 (3): 445-453. March 2017

The European Hematology Association Roadmap for European Hematology Research: a consensus document.
Engert, A., Balduini, C., Brand, A., Coiffier, B., Cordonnier, C., Doehner, H., Duyvene' de Wit, T., Eichinger, S., Fibbe, W., Green, T., de Haas, F., Iolascon, A., Jaffredo, T., Rodeghiero, F., Salles, G. and Schuringa, J.J.
Haematologica 101 (2): 115-208. February 2016

ASXL1 mutations in younger adult patients with acute myeloid leukemia: a study by the German-Austrian Acute Myeloid Leukemia Study Group.
Paschka, P., Schlenk, R.F., Gaidzik, V.I., Herzig, J.K., Aulitzky, T., Bullinger, L., Späth, D., Teleanu, V., Kündgen, A., Köhne, C.H., Brossart, P., Held, G., Horst, H.A., Ringhoffer, M., Götze, K., Nachbaur, D., Kindler, T., Heuser, M., Thol, F., Ganser, A., Döhner, H. and Döhner, K.
Haematologica 100 (3): 324-330. March 2015

Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia.
Yun, H., Damm, F., Yap, D., Schwarzer, A., Chaturvedi, A., Jyotsana, N., Lübbert, M., Bullinger, L., Döhner, K., Geffers, R., Aparicio, S., Humphries, R.K., Ganser, A. and Heuser, M.
Haematologica 99 (9): 1456-1464. September 2014

Genome-wide genotyping of acute myeloid leukemia with translocation t(9;11)(p22;q23) reveals novel recurrent genomic alterations.
Kühn, M.W.M., Bullinger, L., Gröschel, S., Krönke, J., Edelmann, J., Rücker, F.G., Eiwen, K., Paschka, P., Gaidzik, V.I., Holzmann, K., Schlenk, R.F., Döhner, H. and Döhner, K.
Haematologica 99 (8): 133-135. August 2014

HOXA/PBX3 knockdown impairs growth and sensitizes cytogenetically normal acute myeloid leukemia cells to chemotherapy.
Dickson, G.J., Liberante, F.G., Kettyle, L.M., O'Hagan, K.A., Finnegan, D.P.J., Bullinger, L., Geerts, D., McMullin, M.F., Lappin, T.R.J., Mills, K.I. and Thompson, A.
Haematologica 98 (8): 1216-25. August 2013

Rabbit antithymocyte globulin (Thymoglobulin(R)) impairs the thymic output of both conventional and regulatory CD4(+) T cells after allogeneic hematopoietic stem cell transplantation in adult patients.
Na, I.K., Wittenbecher, F., Dziubianau, M., Herholz, A., Mensen, A., Kunkel, D., Blau, O., Blau, I., Thiel, E., Uharek, L., Scheibenbogen, C., Rieger, K. and Thiel, A.
Haematologica 98 (1): 23-30. January 2013

Clinical cardiac safety profile of nilotinib.
Kim, T.D., le Coutre, P., Schwarz, M., Grille, P., Levitin, M., Fateh-Moghadam, S., Giles, F.J., Doerken, B., Haverkamp, W. and Koehncke, C.
Haematologica 97 (6): 883-889. June 2012

Eukaryotic initiation factor 2α phosphorylation is required for B cell maturation and function in mice.
Mielke, N., Schwarzer, R., Calkhoven, C.F., Kaufman, R., Doerken, B., Leutz, A. and Jundt, F.
Haematologica 96 (9): 1261-1268. September 2011

Common clonal origin of an acute B lymphoblastic leukemia and a Langerhans' cell sarcoma: evidence for hematopoietic plasticity.
Ratei, R., Hummel, M., Anagnostopoulos, I., Jaehne, D., Arnold, R., Doerken, B., Mathas, S., Thomas, B., Dudeck, O., Ludwig, W.D. and Stein, H.
Haematologica 95 (9): 1461-1466. September 2010

A modified EBMT risk score and the hematopoietic cell transplantation-specific comorbidity index for pre-transplant risk assessment in adult acute lymphoblastic leukemia.
Terwey, T.H., Hemmati, P.G., Martus, P., Dietz, E., Vuong, L.G., Massenkeil, G., Doerken, B. and Arnold, R.
Haematologica 95 (5): 810-818. May 2010

Impact of additional chromosomal aberrations and BCR-ABL kinase domain mutations on the response to nilotinib in Philadelphia chromosome-positive chronic myeloid leukemia.
Kim, T.D., Tuerkmen, S., Schwarz, M., Koca, G., Nogai, H., Bommer, C., Doerken, B., Daniel, P. and le Coutre, P.
Haematologica 95 (4): 582-588. April 2010

Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo.
Heringer-Walther, S., Eckert, K., Schumacher, S.M., Uharek, L., Wulf-Goldenberg, A., Gembardt, F., Fichtner, I., Schultheiss, H.P., Rodgers, K. and Walther, T.
Haematologica 94 (6): 857-860. June 2009

Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Britton, J.A., Khan, A.E., Rohrmann, S., Becker, N., Linseisen, J., Nieters, A., Kaaks, R., Tjonneland, A., Halkjaer, J., Severinsen, M.T., Overvad, K., Pischon, T., Boeing, H., Trichopoulou, A., Kalapothaki, V., Trichopoulos, D., Mattiello, A., Tagliabue, G., Sacerdote, C., Peeters, P.H., Bueno-de-Mesquita, H.B., Ardanaz, E., Navarro, C., Jakszyn, P., Altzibar, J.M., Hallmans, G., Malmer, B., Berglund, G., Manjer, J., Allen, N., Key, T., Bingham, S., Besson, H., Ferrari, P., Jenab, M., Boffetta, P., Vineis, P. and Riboli, E.
Haematologica 93 (11): 1666-1677. November 2008

Detection of minimal residual disease in unselected patients with acute myeloid leukemia using multiparameter flow cytometry for definition of leukemia-associated immunophenotypes and determination of their frequencies in normal bone marrow.
Kern, W., Danhauser-Riedl, S., Ratei, R., Schnittger, S., Schoch, C., Kolb, H.J., Ludwig, W.D., Hiddemann, W. and Haferlach, T.
Haematologica 88 : 646-653. 1 June 2003

Quantification of human cells in NOD/SCID mice by duplex real-time polymerase reaction.
Nitsche, A., Becker, M., Junghahn, I., Aumann, J., Landt, O., Fichtner, I., Wittig, B. and Siegert, W.
Haematologica 86 : 693-699. 1 January 2001

Impact of CD133 (AC133) and CD90 expression analysis for acute leukemia immunophenotyping.
Wuchter, C., Ratei, R., Spahn, G., Schoch, C., Harbott, J., Schnittger, S., Haferlach, T., Creutzig, U., Sperling, C., Karawajew, L. and Ludwig, W.D.
Haematologica 86 : 154-161. 1 January 2001

Clinical significance of P-glycoprotein expression and function for response to induction chemotherapy, relapse rate and overall survival in acute leukemia.
Wuchter, C., Karawajew, L., Ruppert, V., Schrappe, M., Buechner, T., Schoch, C., Haferlach, T., Harbott, J.N., Ratei, R., Doerken, B. and Ludwig, W.D.
Haematologica 85 : 711-721. 1 July 2000

Review

Impact of immunophenotyping on management of acute leukemias.
Bene, M.C., Bernier, M., Castoldi, G., Faure, G.C., Knapp, W., Ludwig, W.D., Matutes, E., Orfao, A. and van't Veer, M.
Haematologica 84 : 1024-1034. 1 November 1999

Expression of the stem cell factor receptor c-kit (CD117) in acute leukemias.
Sperling, C., Schwartz, S., Buechner, T., Thiel, E. and Ludwig, W.D.
Haematologica 82 : 617-621. 1 January 1997

Letter

Frequent, high density expression of surface CD38 as a potential therapeutic target in adult T-lineage acute lymphoblastic leukemia.
Koslowski, S., Glauben, R., Habringer, S., Burmeister, T., Keller, U., Brüggemann, M., Gökbuget, N. and Schwartz, S.
Haematologica 109 (2): 661-665. February 2024

Rituximab therapy after pediatric hematopoietic stem cell transplantation can cause prolonged B cell impairment and increases the risk for infections - a retrospective matched cohort study.
Launspach, M., Temel, D., Ohlendorf, E., Zirngibl, F., Materne, B., Oevermann, L., Deubzer, H.E., Henssen, A.G., Künkele, A., Hundsdörfer, P., von Bernuth, H., Pruß, A., Eggert, A., von Stackelberg, A., Lang, P. and Schulte, J.H.
Haematologica 108 (1): 267-272. January 2023

Clonal hematopoiesis of indeterminate potential-related epigenetic age acceleration correlates with clonal hematopoiesis of indeterminate potential clone size in patients with high morbidity.
Feldkamp, J.D., Vetter, V.M., Arends, C.M., Lang, T.J.L., Bullinger, L., Damm, F., Demuth, I. and Frick, M.
Haematologica 107 (7): 1703-1708. July 2022

Transcription factor 4 (TCF4) expression predicts clinical outcome in RUNX1 mutated and translocated acute myeloid leukemia.
In't Hout, F.E.M., Gerritsen, M., Bullinger, L., Van der Reijden, B.A., Huls, G., Vellenga, E. and Jansen, J.H.
Haematologica 105 (9): e454-457. 1 September 2020

The long non-coding RNA Cancer Susceptibility 15 (CASC15) is induced by isocitrate dehydrogenase (IDH) mutations and maintains an immature phenotype in adult acute myeloid leukemia.
Grasedieck, S., Ruess, C., Krowiorz, K., Lux, S., Pochert, N., Schwarzer, A., Klusmann, J.H., Jongen-Lavrencic, M., Herold, T., Bullinger, L., Pollack, J.R., Rouhi, A. and Kuchenbauer, F.
Haematologica 105 (9): e448-e453. September 2020

Clonal hematopoiesis in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis.
Arends, C.M., Weiss, M., Christen, F., Eulenberg-Gustavus, C., Rousselle, A., Kettritz, R., Eckardt, K.U., Chan, W., Hoyer, K., Frick, M., Bullinger, L., Bieringer, M., Schreiber, A. and Damm, F.
Haematologica 105 (6): e264-e267. June 2020

Chromothripsis is linked to alteration, cell cycle impairment, and dismal outcome in acute myeloid leukemia with complex karyotype.
Rücker, F.G., Dolnik, A., Blätte, T.J., Teleanu, V., Ernst, A., Thol, F., Heuser, M., Ganser, A., Döhner, H., Döhner, K. and Bullinger, L.
Haematologica 103 (1): e17-e20. January 2018

Acute myeloid leukemia with mutated nucleophosmin 1: an immunogenic acute myeloid leukemia subtype and potential candidate for immune checkpoint inhibition.
Greiner, J., Hofmann, S., Schmitt, M., Götz, M., Wiesneth, M., Schrezenmeier, H., Bunjes, D., Döhner, H. and Bullinger, L.
Haematologica 102 (12): e499-e501. December 2017

MicroRNA expression-based outcome prediction in acute myeloid leukemia: novel insights through cross-platform integrative analyses.
Shivarov, V., Dolnik, A., Lang, K.M., Krönke, J., Kuchenbauer, F., Paschka, P., Gaidzik, V.I., Döhner, H., Schlenk, R.F., Döhner, K. and Bullinger, L.
Haematologica 101 (11): e454-e456. November 2016

Organ siderosis and hemophagocytosis during acute graft-versus-host disease.
Nogai, A., Shi, Y., Perez-Hernandez, D., Cordes, S., Mengwasser, J., Mertlitz, S., Riesner, K., Kalupa, M., Erdmann, J.H., Ziebig, R., Dittmar, G. and Penack, O.
Haematologica 101 (8): e344-e346. August 2016

Differences in the expression pattern of apoptosis-related molecules between childhood and adult de novo acute myeloid leukemia.
Wuchter, C., Richter, S., Oltersdorf, D., Karawajew, L., Ludwig, W.D. and Tamm, I.
Haematologica 89 : 363-364. 1 March 2004

Editorial

A CD205-directed antibody drug conjugate - lymphoma precision oncology or sophisticated chemotherapy?
Rieke, D.T. and Keller, U.
Haematologica 105 (11): 2504-2506. 1 November 2020

Venetoclax resistance and acquired mutations in chronic lymphocytic leukemia.
Tausch, E., Close, W., Dolnik, A., Bloehdorn, J., Chyla, B., Bullinger, L., Döhner, H., Mertens, D. and Stilgenbauer, S.
Haematologica 104 (9): e434-e437. September 2019

The pathogenesis of classical Hodgkin's lymphoma: what can we learn from analyses of genomic alterations in Hodgkin and Reed-Sternberg cells?
Janz, M. and Mathas, S.
Haematologica 93 (9): 1292-1295. September 2008