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| Item Type: | Article |
|---|---|
| Title: | 7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions |
| Creators Name: | Behrens, J.R., Wanner, J., Kuchling, J., Ostendorf, L., Harms, L., Ruprecht, K., Niendorf, T., Jarius, S., Wildemann, B., Gieß, R.M., Scheel, M., Bellmann-Strobl, J., Wuerfel, J., Paul, F. and Sinnecker, T. |
| Abstract: | BACKGROUND: Baló's concentric sclerosis (BCS) is a rare condition characterized by concentrically layered white matter lesions. While its pathogenesis is unknown, hypoxia-induced tissue injury and chemotactic stimuli have been proposed as potential causes of BCS lesion formation. BCS has been suggested to be a variant of multiple sclerosis (MS). Here, we aimed to elucidate similarities and differences between BCS and MS by describing lesion morphology and localization in high-resolution 7 Tesla (7 T) magnetic resonance imaging (MRI) scans. METHODS: Ten patients with Baló-type lesions underwent 7 T MRI, and 10 relapsing remitting MS patients served as controls. The 7 T MR imaging protocol included 3D T(1)-weighted (T(1)w) magnetization-prepared rapid gradient echo, 2D high spatial resolution T(2)*-weighted (T(2)*w) fast low-angle shot and susceptibility-weighted imaging. RESULTS: Intralesional veins were visible in the center of all but one Baló-type lesion. Four Baló-type lesions displayed inhomogeneous intralesional T(2)*w signal intensities, which are suggestive of microhemorrhages or small ectatic venules. Eight of 10 BCS patients presented with 97 additional lesions, 36 of which (37%) had a central vein. Lesions involving the cortical gray matter and the U-fibers were not detected in BCS patients. CONCLUSION: Our findings support the hypothesis that BCS and MS share common pathogenetic mechanisms but patients present with different lesion phenotypes. |
| Source: | Annals of Clinical and Translational Neurology |
| ISSN: | 2328-9503 |
| Publisher: | Wiley-Blackwell |
| Volume: | 5 |
| Number: | 8 |
| Page Range: | 900-912 |
| Date: | August 2018 |
| Official Publication: | https://doi.org/10.1002/acn3.572 |
| PubMed: | View item in PubMed |
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