![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
3MB |
![[thumbnail of Supplementary Material]](https://mdc-test.eprints-hosting.org/style/images/fileicons/other.png) |
Other (Supplementary Material)
6MB |
| Item Type: | Article |
|---|---|
| Title: | Dispersal strategies shape persistence and evolution of human gut bacteria |
| Creators Name: | Hildebrand, F., Gossmann, T.I., Frioux, C., Özkurt, E., Myers, P.N., Ferretti, P., Kuhn, M., Bahram, M., Nielsen, H.B. and Bork, P. |
| Abstract: | Human gut bacterial strains can co-exist with their hosts for decades, but little is known about how these microbes persist and disperse, and evolve thereby. Here, we examined these processes in 5,278 adult and infant fecal metagenomes, longitudinally sampled in individuals and families. Our analyses revealed that a subset of gut species is extremely persistent in individuals, families, and geographic regions, represented often by locally successful strains of the phylum Bacteroidota. These "tenacious" bacteria show high levels of genetic adaptation to the human host but a high probability of loss upon antibiotic interventions. By contrast, heredipersistent bacteria, notably Firmicutes, often rely on dispersal strategies with weak phylogeographic patterns but strong family transmissions, likely related to sporulation. These analyses describe how different dispersal strategies can lead to the long-term persistence of human gut microbes with implications for gut flora modulations. |
| Keywords: | Metagenomics, Population Genetics, Gut Microbiome, Strain Resolution, Bacterial Dispersal, Antibiotics |
| Source: | Cell Host & Microbe |
| ISSN: | 1931-3128 |
| Publisher: | Elsevier / Cell Press |
| Volume: | 29 |
| Number: | 7 |
| Page Range: | 1167-1176 |
| Date: | 14 June 2021 |
| Official Publication: | https://doi.org/10.1016/j.chom.2021.05.008 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
