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| Item Type: | Article |
|---|---|
| Title: | Missense variant E1295K of sodium channel SCN5A associated with recurrent ventricular fibrillation and myocardial inflammation |
| Creators Name: | Poller, W., Escher, F., Haas, J., Heidecker, B., Schultheiss, H.P., Attanasio, P., Skurk, C., Haghikia, A., Meder, B. and Klaassen, S. |
| Abstract: | SCN5A was considered an exclusively cardiac expressed ion channel but discovered to also act as a novel innate immune sensor. We report on a young SCN5A variant carrier with recurrent ventricular fibrillation and massive myocardial inflammation whose peculiar clinical course is highly suggestive of such a dual role of SCN5A. |
| Keywords: | Inflammation, Innate Immune, Response, Ion Channel Diseases, Ion Channel, Functions, Variant Screening |
| Source: | JACC: Case Reports |
| ISSN: | 2666-0849 |
| Publisher: | Elsevier |
| Volume: | 4 |
| Number: | 5 |
| Page Range: | 280-286 |
| Date: | 2 March 2022 |
| Official Publication: | https://doi.org/10.1016/j.jaccas.2022.01.016 |
| PubMed: | View item in PubMed |
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