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| Item Type: | Article |
|---|---|
| Title: | Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis |
| Creators Name: | Brune-Ingebretsen, S., Høgestøl, E.A., de Rosbo, N.K., Berg-Hansen, P., Brunborg, C., Blennow, K., Zetterberg, H., Paul, F., Uccelli, A., Villoslada, P., Harbo, H.F and Berge, T. |
| Abstract: | Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response to drugs and to prognosticate disease course. Here we show a moderate correlation between sNfL and lymphocyte cell subpopulations, and our data furthermore suggest that sNfL and specific immune cell subpopulations together could predict future disease worsening in MS. |
| Keywords: | Multiple Sclerosis, Serum Neurofilament Light Chain, Immune Cell Subset Frequencies, Biomarkers, Disease Worsening |
| Source: | Journal of Neuroimmunology |
| ISSN: | 0165-5728 |
| Publisher: | Elsevier |
| Volume: | 382 |
| Page Range: | 578175 |
| Date: | 15 September 2023 |
| Official Publication: | https://doi.org/10.1016/j.jneuroim.2023.578175 |
| PubMed: | View item in PubMed |
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