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| Item Type: | Article |
|---|---|
| Title: | Fetal growth restriction induced by maternal gal-3 deficiency is associated with altered gut-placenta axis |
| Creators Name: | Xie, Y., Zhao, F., Wang, Y., Borowski, S., Freitag, N., Tirado-Gonzalez, I., Hofsink, N., Matschl, U., Plösch, T., Garcia, M.G. and Blois, S.M. |
| Abstract: | Adverse intrauterine conditions may cause fetal growth restriction (FGR), a pregnancy complication frequently linked to perinatal morbidity and mortality. Although many studies have focused on FGR, the pathophysiological processes underlying this disorder are complex and incompletely understood. We have recently determined that galectin-3 (gal-3), a β-galactoside-binding protein, regulates pregnancy-associated processes, including uterine receptibility, maternal vascular adaptation and placentation. Because gal-3 is expressed at both sides of the maternal-fetal interface, we unraveled the contribution of maternal- and paternal-derived gal-3 on fetal-placental development in the prenatal window and its effects on the post-natal period. Deficiency of maternal gal-3 induced maternal gut microbiome dysbiosis, resulting in a sex-specific fetal growth restriction mainly observed in female fetuses and offspring. In addition, poor placental metabolic adaptions (characterized by decreased trophoblast glycogen content and insulin-like growth factor 2 (Igf2) gene hypomethylation) were only associated with a lack of maternal-derived gal-3. Paternal gal-3 deficiency caused compromised vascularization in the placental labyrinth without affecting fetal growth trajectory. Thus, maternal-derived gal-3 may play a key role in fetal-placental development through the gut-placenta axis. |
| Keywords: | Fetal Development, Fetal Growth Retardation, Galectin 3, Gastrointestinal Microbiome, Insulin-Like Growth Factor II, Inbred C57BL Mice, Placenta, Pregnancy, Trophoblasts, Animals, Mice |
| Source: | Cell Death & Disease |
| ISSN: | 2041-4889 |
| Publisher: | Nature Publishing Group |
| Volume: | 15 |
| Number: | 8 |
| Page Range: | 575 |
| Date: | 8 August 2024 |
| Official Publication: | https://doi.org/10.1038/s41419-024-06962-6 |
| PubMed: | View item in PubMed |
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